Nitroanilinesulfonic acids of the formula ##STR1## where R is C.sub.1 -C.sub.4 -alkyl are prepared by sulfonation of 3-nitro-N-alkylanilines using oleum, and are reduced to 3-(N-alkylamino)aniline-4-sulfonic acids.

The compounds are hydroxamic acids of alicyclic amino acids, and esters of said compounds, all of which have valuable pharmacodynamic properties in that they suppress the immune response in warm-blooded animals.

Novel .alpha.-halo-p-cycloalkylphenylacetic acids and their derivatives have been prepared. Compounds of this invention possess useful anti-inflammatory, analgesic and antipyretic properties.

A method of preparing carboxylic acids is provided by heating an acylhydroximyl halide in an aqueous medium at elevated temperatures.

This invention relates to phenylacetic acid derivatives having the formula: ##STR1## in which A represents a grouping ##STR2## R, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, represent each hydrogen or an alkyl group, and represents a single or double carbon-carbon bond; and their salts with inorganic and organic bases. Said compounds possess anti-inflammatory and analgesic activities that make them therapeutically useful, in particular for the treatment of rheumatic disease...

The present invention relates to a process for producing novel hydroxyether carboxylic acids and their salts containing at least one glycolic acid ether and at least two carboxylic acids as well as to these compounds per se.

The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.

Novel substituted 1-pyridyloxyphenyl-3-benzoylparabanic acids of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 and R.sub.3, each independently of the other, are halogen or C.sub.1 -C.sub.4 alkyl, R.sub.4 is hydrogen or halogen, R.sub.5 is halogen or C.sub.1 -C.sub.4 alkyl which is halogenated by fluorine and/or chlorine, and n is 0, 1 or 2, and the pyridyloxy group is linked to the phenyl group in the 3- or 4-position. A process for the preparation ...

This disclosure describes novel [Bis(phenyl or substituted phenyl)alkyl]amino benzoic acids, esters, and derivatives thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.

The present invention relates to new industrial products, namely halogeno-benzhydrylsulfinylacetohydroxamic acids of formula: ##STR1## wherein: X.sub.1 is F, Cl, Br or CF.sub.3 ; and X.sub.2, which may be identical to or different from X.sub.1, is H, F, Cl, Br or CF.sub.3. These products are useful in therapeutics, particularly as substances acting on the CNS.