New substituted derivatives of thiazolidine-, thiazane- and related carboxylic acids which have the general formula ##STR1## are useful as angiostensin converting enzyme inhibitors.

New substituted derivatives of thiazolidine-, thiazane- and related carboxylic acids which have the general formula ##STR1## are useful as angiostensin converting enzyme inhibitors.

The invention provides new acetohydroxamic acid derivatives, having interesting properties on the central nervous system, of the formula: R.sub.1 R.sub.2 R.sub.3 C-CO-NHOH, in which R.sub.2 and R.sub.3 are each hydrogen or C.sub.1-6 alkyl, and R.sub.1 is C.sub.1-6 alkyl Z.sub.1 Z.sub.2 N (where Z.sub.1 and Z.sub.2 are each phenyl, substituted phenyl, or cycloalkyl), substituted hydantoinyl, benzhydroxylcarboxamido, Z.sub.3 CH.sub.2 -- (where Z.sub.3 = optionally substituted aryl), Z.sub.4 -A- (w...

Certain mono- and disubstituted-S-sulfamylbenzoic acids, many of which are novel, and their use in lowering blood lipid levels in mammals.

New carboxyalkylacylamino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

The invention concerns novel racemic and optically active mono- and di-hydroxy alkanoic acids bearing phenyl and/or alkyl substituents, processes for their preparation, and pharmaceutical compositions for therapeutic use in the treatment of duodenal or gastric ulcers. Representative compounds of the invention are 2-(5.beta.-n-butyl-4.beta.-hydroxy-2-oxo-tetrahydrofuran-3.beta.-yl)-2.alp ha.-methyl-acetic acid and 3.alpha.-methyl-5.beta.-(1.beta.-hydroxy-n-pentyl)-2-oxo-tetrahydrofuran-4 .beta.-y...

Substituted 3,3-diphenylphthalides, useful as color precursors, particularly in the art of pressure-sensitive duplicating systems, are prepared by condensing substituted 2-benzoylbenzoic acids with substituted anilines.

Therapeutic compositions comprising 2-(hydroxy-substituted-4-biphenylyl)propionic acids and methods of treatment of inflammation, pain, fever and preventing blood platelet aggregation with these compounds.

The present invention relates to new nitrogen-containing organophosphorus compounds having alkoxy or alkyl substituents bonded to phosphorus in ester or phosphine oxide structures and to organophosphorus acids that can be produced by hydrolysis of the esters. ##EQU1## R is alkyl or haloalkyl of one to five carbon atoms, R' is R, OH or OR, R" is hydrogen, alkyl or aryl of one to 15 carbon atoms, R'" is alkyl, alkenyl, aryl, chloroaryl or bromoaryl groups of one to 15 carbon atoms, and Z is CO, CS...

Novel biphenyleneacetic acids and derivatives thereof which are useful in the treatment of inflammation. Also included are processes for the preparation of the biphenyleneacetic acid materials and therapeutic compositions and methods of treatment employing said agents.