The present invention relates to the field of organic synthesis and more specifically to a process for the preparation of Michael-adducts, as defined below, by reacting a .beta.,.beta.- or a .alpha.,.beta.-disubstituted, or a .alpha.,.beta.,.beta.-trisubstituted, .alpha.,.beta.-unsaturated ketone (I) with a .beta.-ketoester or a .beta.-diketone (II) in presence of a suitable catalyst of formula M(X).sub.n, according to scheme 1: ##STR1##

Disclosed is an improvement to the method of determining the concentration of a hemoglobin adduct in a blood sample by the steps of assaying the blood sample for the total amount of hemoglobin, assaying the blood sample for the hemoglobin adduct, and dividing the hemoglobin adduct concentration by the total hemoglobin concentration. The improvement involves normalizing the measurement of the hemoglobin adduct to the total amount of hemoglobin in the blood sample.

The application relates to a process for producing high-purity bis(4-hydroxyaryl)alkanes from adducts of bis(4-hydroxyaryl)alkanes and aromatic hydroxy compounds, which are obtained by acid-catalysed reaction of the aromatic hydroxy compounds with ketones.

The invention relates to addition compounds suitable for use as wetting agents and dispersants and obtainable by reacting monofunctional or polyfunctional aromatic epoxides with polyoxyalkylenemonoamines having a number-average molecular weight of >400 g/mol, one primary or secondary amino group and at least 4 ether oxygen atoms per molecule, from 90 to 100% of the epoxide groups of the starting material having undergone reaction, the weight fraction of aromatic groups in the addition compoun...

Described are diester amine adducts of formula (1) wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 are each independently of one another C.sub.4 -C.sub.22 alkyl; C.sub.2 -C.sub.22 alkenyl; or C.sub.5 -C.sub.7 cycloalkyl; X.sub.1 and X.sub.2 are each independently of the other hydrogen, C.sub.1 -C.sub.4 alkyl; C.sub.2 -C.sub.4 hydroxyalkyl or C.sub.2 -C.sub.4 hydroxyhaloalkyl; Y is a radical of formula (1b); A.sub.1 is C.sub.2 -C.sub.3 alkylene or 2-hydroxy-n-propylene; X.sub.3 is hydrogen; C.sub.1 -C...

New adducts are produced from the reaction of vinyl dioxo compounds with anhydrides, epoxyesters, lactones, and lactams, and such adducts are useful for preparing curable coating compositions.

Adducts of vinyldioxo compounds comprising a crosslinkable silyl-functional terminal group are disclosed. Such adducts are useful for preparing curable coating compositions.

Disclosed is an acid-funtionalized polyurethane adduct and a process for the preparation of such adduct. The adduct having a linear or preferably branched structure comprises a plurality of internal urethane linkages and one or more terminal carboxylic acid groups per molecule. Such acid-funtionalized polyurethane adducts find value in the manufacture of crosslinked aqueous rubber latexes such as might be used in paint compositions.

There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA residues, conjugated to a polyamine backbone molecule, e.g. polylysine. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein. For example, adducts of a macrocyclic chelant can be formed by ...

Michael addition conducted in the presence of a zinc-amine complex and additional amounts of the amine component results in product with high diastereomeric excess.