Disclosed are compounds that can serve as melatonin analogue prodrugs and that are soluble in aqueous solvents. Melatonin or melatonin analogues having modifications to the indole moiety are coupled to a tertiary amine to form a quaternary amine such that there is a saturated two-carbon linkage between the carbonyl of the melatonin structure and the amine nitrogen. This structure is stable in acidic environments, but is unstable at basic or neutral pH. Therefore, these melatonin analogue prodrug...

A p.c.m. encoder comprises a high accuracy linear A/D converter followed by a digital high pass filter, a d.c. offset circuit and a digital compressor. The high pass filter removes any d.c. offset from the encoded signal and the offset circuit then reintroduces a controlled amount of d.c. offset. By this means the performance can be improved especially in regard to idle noise and crosstalk enhancement.

A linear A to D converter comprising a combiner means to which an input signal to be converted is fed, the input signal being combined subtractively or additively with an analogue feedback signal, and the combiner means being arranged to feed an A to D flash converter via an amplifier, which A to D flash converter is arranged to feed a D to A converter which provides the feedback signal. The D to A converter comprises a digital overflowing accumulator also arranged to drive a finite impulse resp...

Compounds having somatostatin activity of the following Formula I, ##STR1## wherein, R.sup.1 is aryl, substituted-aryl, and aryl-(lower-alkyl)-; R.sup.2 is lower alkyl, amino substituted lower alkyl, -carboxy-(lower-alkyl), -carbamic acid-(lower-alkyl) and -carboxy-(lower-alkyl)-aryl; and R.sup.3 and R.sup.4 are independently, lower-alkyl, aryl, substituted-aryl, (substituted-aryl)-(lower-alkyl)-, heteroaryl, (heteroaryl)-(lower-alkyl)-, substituted-heteroaryl, (substituted heteroaryl)-(lower-al...

Crystals of glucagon-like peptide-1 (GLP-1) and GLP-1 analogues, and processes for preparation of crystals of GLP-1 and GLP-1 analogues.

An analogue display has a circle of electrically-energizable elements that are selectively energized so as to represent time. A rotatable setting wheel has a knurled edge that projects from the display casing. A leaf spring engages the knurled edge, the spring having a piezo-electric element on its surface which produces pulses dependent on rotation and direction of rotation of the wheel. Different elements are energized around the circle, as the wheel is rotated, according to the speed and dire...

An compass having an electronic magnetic field sensor and an analog directional display is disclosed wherein a signal from the field sensor proportional to one component of the earth's magnetic field is alternated in polarity and integrated to produce a triangular waveform the frequency of which is proportional to the strength of that field component and wherein a triangular waveform having a frequency proportional to the second component of the earth's magnetic field is produced in the same man...

The invention provides a polypeptide of calcitonin analogue and use thereof. The polypeptide has such an amino acid sequence that proline-amide residue (Pro-NH.sub.2) at C-terminal of native eel calcitonin is substituted to a homoserine amide residue (Hse.multidot.NH.sub.2).

Compound of formula (I): ##STR1## wherein: n is 0, 1 or 2, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, perhaloalkyl, cycloalkyl, cycloalkylalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, acyloxy, carboxy, nitro, cyano, aminocarbonyl (optionally substituted), and the groups (CH.sub.2).sub.p --NR.sub.a R.sub.b and --O--C(O)--N--R.sub.a R.sub.b, with p, R.sub.a and R.sub.b being as defined in the description, or two...

An intermediate compound which is a perhydrofuro [3,2-6] pyrrole of the formula: ##STR1## wherein: R.sub.2 is hydrogen or C.sub.1-4 alkyl; and R.sub.3 is C.sub.4-9 alkyl, C.sub.5-7 cycloalkyl or C.sub.5-7 cycloalkyl C.sub.1-6 alkyl; for use in the synthesis of prostacyclin aza analogues having anti-thrombotic activity.