The invention provides a safe and economical nonprescription combination of acetaminophen, aspirin and caffeine (APAP/ASA/CAF) for use in treating migraine pain and the cluster of symptoms characteristic of migraine attack, such as nausea, photophobia, phonophobia and functional disabilities. The use of the APAP/ASA/CAF combination is also effective in aborting the prodrome phase of a migraine attack.

An aqueous-based formulation for coating aspirin granules to provide granules that may be compressed into tablets and that show approximately zero-order release kinetics for release rates of 5 to 15 mg/hour over a period extending five to eight hours is provided. The coating formulation preferably consists of an acrylate/methacrylate copolymer, hydroxypropylmethylcellulose, sodium chloride and talc. A film-coated tablet comprised of the coated granules, filler granules, excipients, binders and d...

A capsule product preferably containing a high dosage of aspirin in powder or granulated form and at least one akaline tablet or pellet; the improvement in which said alkaline tablet or pellet comprises magnesium carbonate, calcium carbonate and a magnesium oxy component such as magnesium oxide, magnesium hydroxide or the combination of magnesium oxide and magnesium hydroxide. The alkaline tablet is preferably dimensioned so that it will contain a maximum amount of material in a minimum volume e...

A method for preparing an easily-swallowed, powder-free, gastric-disintegrable and thinly-coated aspirin tablet, which does not have the characteristic aspirin taste, does not produce the esophageal discomfort of an uncoated aspirin tablet and does not disintegrate in the stomach materially slower than the uncoated aspirin tablet, which comprises aqueous spray-coating hydroxypropyl methylcellulose onto all exterior surfaces of an aspirin tablet, the amount of hydroxypropyl methylcellulose being ...

A new class of analgesics is provided by substances that inhibit breakdown of endogenous substance such as enkephalins and/or endorphins. The analgesic effect of an enkephalin breakdown inhibitor is greatly enhanced by being combined with an antipyretic, anti-inflammatory analgesic, herein designated as an aspirin-type drug. Specifically, both D-phenylalanine and D-leucine, each an enkephalin breakdown inhibitor, when used separately provides excellent analgesia in animals and man without develo...