This disclosure relates to a high speed combinatorial 8 by 8 digital multiplier suitable for implementation on a single semiconductor chip including an encoder for implementing the Modified Booth Algorithm to encode the eight multiplier digits. The encoder includes five subsections which generate a plurality of control signals. Each of the plurality of control signals is inputted into a separate one of five multiplexor circuits each of which also receives inputs representative of eight multiplic...

A tree-type combinatorial logic circuit comprising a plurality of identical functional units which may be arranged to operate as an N-bit magnitude comparator, a carry generator for an N-bit adder, or a parity predictor for 2N-bit binary counter. Each of the units is provided with four input terminals and two output terminals. The units are arranged to form a binary tree. Each unit has an internal logic circuit which generates outputs of G.sub.K*l =G.sub.K VE.sub.K .multidot.g.sub.l and E.sub.K*...

The present invention provides methods for synthesizing arrays of polymers. A barrier to a reaction is applied to select features of the array thereby limiting the reaction to the remaining features.

Apparatus and methods are described for split synthesis combinatorial chemistry that provides candidate libraries where an even distribution of theoretical products is obtainable through even mixing during the pooling step, followed by controlled redistribution of the mixed pooled products from the prior addition step into separate synthesis columns, one for each different specie of subunit to be added.

A method of combinatorial multimodal optimization uses a genetic algorithm to find simultaneous global optimal solutions to combinatorial problems. Each individual within the population is associated not only with a fitness value but with a fitness vector, using which the persistence of all of the best individuals into the next generation can be guaranteed. Phenotype as well as genotype analysis is an integral part of the method.

An automatic combinatorial weighing apparatus includes a double collection chute assembly disposed in delivery paths for passage of articles to be weighed. The double collection chute assembly includes an inner collection chute having an outlet and a pair of outer collection chutes having respective outlets, the outlets being connected to timing hoppers, respectively. Articles flow down the inner and outer collection chutes at as equal speeds and in as equal times as possible, the speeds being i...

A combinatorial weighing method and apparatus wherein a value serving as a target for a combinatorial computation is set so that the mean weight value of batches of articles weighed out selectively by plural weighing cycles becomes equal to a preset weight value within preset allowable limits. Combinatorial computations are performed while diminishing the target weight value by a predetermined amount when the mean weight value is greater than the preset weight value, and increasing the target we...

Directly dividing the contents of each sub-pool into the sub-pools for the next step in the synthetic scheme for producing a combinatorial library reduces the standard deviation, .sigma., relative to the standard deviation of the split synthesis method for producing such libraries.

The present invention describes an encoded combinatorial chemical library comprised of a plurality of bifunctional molecules having both a chemical polymer and an identifier oligonucleotide sequence that defines the structure of the chemical polymer. Also described are the bifunctional molecules of the library, and methods of using the library to identify chemical structures within the library that bind to biologically active molecules in preselected binding interactions.

A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.