Predetermined combinatorial libraries of non-peptide compounds are disclosed. Compounds useful for generating such libraries are also disclosed.

A combinatorial pipettor device for the collection of a sample adapted for use with different size microtiter plates. The device comprises an upper plate having first and second halves, each half independently movable between an upper and a lower position, and a lower plate having tip connectors for the attachment of collecting tips. Also included are sample collector members having proximal ends and distal ends and a mechanism for moving at least one half of the upper plate between the upper an...

A combinatorial at-speed scan testing. A processor including a plurality of distributed slave counters. Each distributed slave counter coupled to a group of scan chains, each distributed slave counter to generate shift-enable-flop signals to be received by the group of scan chains coupled to each distributed slave counter, the shift-enable-flop signals based at least in part on an external shift-enable signal received by the processor. A scan test controller coupled to the plurality of distribut...

A processor including a first distributed shift generator associated with a first time domain, wherein the first distributed shift generator is coupled to a first group of scan chains, the first distributed shift generator to send a shift-enable-flop signal to be received by the first group of scan chains. The processor including a second distributed shift generator associated with a second time domain, wherein the second distributed shift generator is coupled to a second group of scan chains, t...

A method for producing arrays by depositing a resist on a substrate, selectively removing a portion of the resist to expose localized areas, dispensing a monomer to occupy a localized area of less than 1 cm.sup.2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 10 different polymers is formed.

A Combinatorial Optical Processor and method for the architecture of optical systems utilizes one or more optical modules, each module including a number of individually addressable optical elements. The optical elements are arranged and addressed in a combinatorial-arithmetic fashion such that a set of optical filter functions are defined, and can be performed, by the optical modules. The number of optical filter functions may be an exponential function of the number of addressable optical elem...

A method for producing polymer arrays by spacing a dispenser a distance from a surface of a support, dispensing a volume containing a monomer in a single coupling step of less than 5 nl to occupy a localized area of less than 1 cm.sup.2 of the surface of the support, allowing the monomer to bind directly or indirectly to the support and repeating the steps to produce an array of at least 100 polymer ligands at a density of 1000 per cm.sup.2 or greater.

Systems and methods for providing in situ, controllably variable concentrations of one, two or more chemical components on a substrate to produce an integrated materials chip. The component concentrations can vary linearly, quadratically or according to any other reasonable power law with one or two location coordinates. In one embodiment, a source and a mask with fixed or varying aperture widths and fixed or varying aperture spacings are used to produce the desired concentration envelope. In an...

Combinatorial libraries are disclosed which are represented by Formula I: wherein: S is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula: ##STR1## which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptors, .delta.-opiate receptors, and K.sup.+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatement of ocular dise...

The invention relates to the formation of novel in vivo combinatorial enzyme complexes for use in screening candidate drug agents for bioactivity.