A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be photoactivated within a subset of channels at the site of immobilized substrate molecules or at a light-addressable site upstream from...

A combinatorial library includes a gelcast substrate defining a plurality of cavities in at least one surface thereof; and a plurality of gelcast test materials in the cavities, at least two of the test materials differing from the substrate in at least one compositional characteristic, the two test materials differing from each other in at least one compositional characteristic.

The present invention is directed to a method of detecting gene expression and analysis of both known and unknown genes. In the method utilizing combinatorial oligonucleotide PCR.TM., no single molecular species of DNA gives rise to more than one fragment in a collection of products which are subsequently amplified and representative of each expressed gene. More specifically, the present invention improves known methods by eliminating the recovery of restriction fragments with two identical ends...

Combinatorial synthesis methods obtain a plurality of compositions having materially different characteristics using an apparatus having a plurality of collectors. A first quantity of fluid reactants are reacted to form a first quantity of product composition. Following completion of the collection of the first quantity of product composition, a second quantity of fluid reactants are reacted to form a second quantity of product composition, the second quantity of product composition being materi...

A combinatorial weighing apparatus of the type in which the batches of article charged in a plurality of hoppers are weighed and the best combination of hoppers which provides a total weight equal to or most closely approximating a target weight within a predetermined tolerance is selected, the batches of article in the hoppers constituting the best combination being then discharged to a collecting chute. The combinatorial weighing apparatus has a plurality of weighing hoppers for receiving batc...

Disclosed in a combinatorial weighing apparatus having a plurality of weighing hoppers, a plurality of weighing machines, associated with respective ones of the weighing hoppers, for weighing or counting articles introduced into each of the weighing hoppers, and a chute for collecting the articles discharged from the weighing hoppers. The apparatus operates by computing combinations based on weight values provided by the weighing machines, and causing weighing hoppers, belonging to a combination...

A combinatorial weighing method and apparatus for supplying a plurality of weighing machines with articles to be weighed, obtaining a plurality of combinations of the weighing machines, each weighing machine combination giving a combination of articles having a combined weight value equal or closest to a target weight value, and selecting an optimum combination from these plural combinations. The optimum combination is one which provides a combination of articles having a combined weight value h...

A combinatorial weighing apparatus in which an operator manually supplies a combinatorial weighing apparatus with articles to be weighed is provided with hopper sets each of which has two weighing hoppers and a single movable pool hopper for supplying the articles to the two weighing hopper in the hopper set. An article supply table is capable of being swung open by virtue of a hinge mechanism, and a plate constituting the top of the supply table is capable of being removed. This arrangement all...

Batches of articles are charged randomly into a plurality of weighing heads, respectively, and weighing data items which are generated respectively by the weighing heads, are added in combinations. The weighing data items from those weighing heads fewer than all of the weighing heads, preferably substantially half of the weighing heads, are picked up and repeatedly added together to provide a wide variety of combinations of added weighing data items. One of such combinations which gives the adde...

A hopper for use in an automatic weighing apparatus, including a hopper body having a discharge port at a lower end of the hopper body, and a gate, swingably supported at an upper edge of the hopper body, for opening and closing the discharge port. The gate has a main body of which at least the left, right and lower edge portions are formed of a flexible material so that the edge portion comes into resilient contact with the inner surface of the discharge port.