Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, i...

A reactor for conducting catalytic chemical reactions has been developed. The reactor has a well having an open end and a closed end. The reactor also has a sleeve having a top end and a bottom end. The bottom end of the sleeve is inserted within the open end of the well. A fluid permeable structure is attached to the sleeve spanning the cross-section thereby defining a chamber between the closed end of the well and the fluid permeable structure. The reactor also has a reactor insert having a fl...

A combinatorial synthesis system is provided which combines pulsed laser deposition techniques with the continuous composition spread technique in which a plurality of targets made of different ingredient materials are arranged in a predetermined relationship and are ablated by an energetic beam focused on the surface of a particular target. By maintaining the energetic beam in a stationary state, the target carousel is rotated so as to bring a particular target in engagement with the energetic ...

The invention provides a method of generating a set of polypeptide antigens derived from a protein (or portion thereof) which is expressed with some degree of sequence heterogeneity among naturally or artificially induced variants of the protein. The purpose is to provide a mix of antigens which can be used to immunize against the variants and, preferably, possible unknown or new variants that may arise.

A combinatorial X-ray diffractor, particularly a combinatorial X-ray diffractor which can measure one row of samples among a plurality of samples arranged into a matrix simultaneously by X-ray diffraction. For the purpose of high throughput screening, a plurality of samples (10) are arranged into a row X1, a row X2, a row X3, and a row X4 on a sample stage and samples in each row are measured simultaneously by X-ray diffraction, measured data are processed by an information processor (20), infor...

A device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.

A combinatorial weighing or counting method of the type in which weight data items from a plurality of weighing machines are combined to find an optimum combination giving a total combined value equal or closest to a target value within preset allowable limits, and the weighed articles are discharged from the weighing machines constituting the optimum combination. Apparatus for practicing the method includes a first storage device provided individually for each of the weighing machines. The meth...

A plurality of weighing data are combined to find a total weight combination closest to a preset value within an allowable preset range. Articles are discharged from those weighing machines which give such a total weight combination. For such a combinatorial computation, the empty weighing machines are first detected from among the weighing machines for which the combinatorial computation has been carried out, and then articles are supplied to the empty weighing machines. Weighing data from a nu...

A combinatorial weighing method and apparatus which operates by weighing plural groups of articles of various weighs by a plurality of weighing machines, finding the sums of all conceivable combinations of these weight values or of given combinations thereof, selecting the combination whose sum is equal to closest to a set value, and discharging the articles from those weighing machines corresponding to the selected combination to obtain articles of a desired weight or number. Between the discha...

A combinatorial weighing apparatus has a distribution table adapted to distribute a material to be weighed and supplied thereto, a plurality of distribution supply devices arranged radially around the distribution table and adapted to receive the material distributed by the distribution table, hoppers disposed below respective distribution supply devices and adapted to receive the material from the distribution supply devices, weight sensors annexed to said hoppers and adapted to weigh the mater...