This invention relates to a bioactive compound and to compositions which contain it. The invention further relates to methods of microtubule stabilization. In particular, it relates to a compound which has cytotoxic properties and which therefore has utility in inter alia anti-tumor treatments.

The present invention relates to a chalcone compound represented by the following general formula: ##STR00001## wherein R.sub.1 and R.sub.2 are taken together with the carbon atom to which they are bound, respectively, to form a hydroxydimethyl hexane ring, or where R.sub.1 is a hydroxyl group, R.sub.2 is an isohexenyl group, a derivative thereof, or a salt thereof. Also, the present invention relates to a therapeutic agent or prophylactic agent for a disease requiring neuronal protection, suppr...

The phosphorus-containing compound of the present invention is represented by the following formula (I), (II) or (III): ##STR1## wherein Z.sup.1, Z.sup.2 and Z.sup.3 each represents a cycloalkane, a cycloalkene, a polycyclic aliphatic hydrocarbon or an aromatic hydrocarbon rings which may have a substituent; R represents a halogen atom, a hydroxyl, a carboxyl, a halocarboxyl(haloformyl), an alkyl, an alkoxy, an alkenyl or an aryl groups; A represents a polyvalent group corresponding to an alkane...

There are provided benzimidazolone compounds that provide a plurality of hues from a single structural formula, and are useful as pigments that offer superior dispersibility in binder resins, as well as benzimidazolone compounds that are useful as pigments, and show minimal flocculation when pigments of two or more different hues are blended together to produced a desired hue.A benzimidazolone compound represented by a general formula (1) shown below. ##STR00001## (wherein, R.sup.1, R.sup.2, R.s...

The present invention is an improved compound bow. In particular the present invention is directed to an adjustable compound bow for hunting and archery with noise reduction features. The preferred embodiment of the bow comprises a riser having a main riser length with two ends, each end attached to an adjustable hub with a limb base. Each limb base preferably has a pocketless flat surface with vibration dampening material. Each hub is secured to the main riser length by an adjustment screw and ...

Since the majority of conventional organic/inorganic composite materials are obtained by mechanical blending of a silsesquioxane and an organic polymer or other means, it was extremely difficult to control the structure of the composite as a molecular agglomerate. In order to solve such a problem, the invention is to provide a silicon compound represented by Formula (1). This novel silicon compound has a living radical polymerization initiating ability for addition polymerizable monomers of a wi...

A gelling agent having a high ability of gelling an oily base which is capable of giving a gel composition having a strong gel strength and a good transparency, a gel composition having a strong gel strength and a good transparency, an external composition having a good feel upon use, a cosmetic preparation having a good feel upon use, and a fragrance composition having a good transparency and a good appearance is provided. An amide compound represented by the following formula 1: ##STR00001## i...

A polymerizable composition for a lens with a high refractive index comprising at least one polythiol compound represented general formula (1): where R is an organic residue except an aromatic group and n is an integer of at least 1, having at least two intramolecular mercapto groups and at least one compound having an intramolecular functional group which can react with a mercapto group; a resin prepared by polymerizing the composition; an optical element and a lens made of the resin; and a pro...

The present invention provides an azo compound represented by the following Formula (I). In Formula (I), R.sup.1 and R.sup.2 respectively independently represent a hydrogen atom, an alkyl group having 1 to 21 carbon atoms, an alkenyl group having 2 to 21 carbon atoms, an aryl group having 6 to 21 carbon atoms or an aralkyl group having 7 to 21 carbon atoms, were R.sup.1 and R.sup.2 may form a hetero ring in combination with a nitrogen atom combined therewith. R.sup.3 represents a halogen atom, a...

A large part of conventional organic-inorganic composite materials is obtained by mechanical blending silsesquioxanes with organic polymers, and therefore it has been very difficult to control the structure thereof as the molecular aggregate of the composite materials. An object of the present invention is to provide a novel silicon compound having a living radical polymerization-initiating ability for an addition-polymerizable monomer and a polymer obtained using the same to thereby solve the p...