Novel chromene compounds having various substituents to exhibit a high color-developing sensitivity and a high density even when dispersed in a high-molecular matrix, and exhibiting a large fading rate, less color when deteriorated, and excellent light resistance in the photochromic properties; photochromic materials containing the chromene compounds; and use thereof.

The present invention provides antitumor methods, formulations, and compounds comprising a cryptophycin.

The present invention relates to a compound of formula (I) (wherein R.sup.1 and R.sup.2 represent an aryl group, a heterocyclic group, an alkyl group, an alkenyl group and the like which are optionally substituted, R.sup.3 represents a hydrogen atom or a hydroxyl group, and X.sup.1 and X.sup.2 represent an oxygen atom or a sulfur atom, or a nitrogen atom which may be substituted), a pharmaceutically acceptable derivative thereof or a salt thereof.The present invention also relates to a pharmaceu...

A novel compound represented by the formula (1): ##STR00001## [R.sup.1 represents hydrogen atom, chlorine atom, or hydroxyl group; X.sup.1 . . . X.sup.2 represents--CH(R.sup.2)--CH(R.sup.3)--, --CH(R.sup.2)--CH(R.sup.3)--CH(R.sup.4)--, etc.; R.sup.2 to R.sup.4represent hydrogen atom, or an alkyl group; A.sup.1, A.sup.11, A.sup.2, and A.sup.21 represent hydrogen atom, or an alkyl group; Y represents --CH(A.sup.3)--, --CH(A.sup.3)--C(A.sup.4)(A.sup.41)--, --CH(A.sup.3)--C(A.sup.4)(A.sup.41)--C(A.s...

A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: ##STR00001## wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R.sup.1 and R.sup.2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R.sup.1 and R.sup.2 may form, together with the adjacen...

Two blades (14, 14) of a slider of a compound needle move back into blade grooves (8, 8) of a needle body (4) on the left and right side of a partition wall (9). An opening (18) is provided at the front ends of the blades (14, 14), and curved portions (19, 19) are provided on the backside of the front ends of the blades. Further, a thick section is provided at the front end of the partition wall (9), and a thin section is provided on the backside of the thick section.When the blades move forward...

The object of the present invention is to provide a compound having a treatment effect based on a chemokine inhibitory activity, which is satisfactory as a pharmaceutical product for oral administration.The present inventors have found that the following benzylpiperidine derivative (the formula (1)) has a chemokine inhibitory activity. Further intensive studies have resulted in successful enhancement of the chemokine inhibitory activity and stability in blood of the present compound, as well as ...

A polymer compound which is a polyphenylene co-condensation polymer consisting substantially of paraphenylene group and metaphenylene group and improved in forming ability and functions, wherein the ratio of metaphenylene group is in the range of 60 to 95%.

A novel monomer compound having a lactone moiety of the present invention can be converted into polymers usable as resist materials with excellent properties, etc., and an alcohol compound having a lactone moiety of the invention is useful as a material for the monomer compound. The compounds are represented by the following general formula [1]: ##STR00001## wherein one of R.sup.1 and R.sup.2 represents a hydrogen atom, an acryloyl group, or a methacryloyl group, and the other represents an alky...

A compound cigarette filter, the filter having the ability to deliver substantially constant tar and nicotine as the cigarette is smoked. The compound filter comprises a barrier positioned upstream and in abutting relationship with at least one filter segment, the barrier containing passageways permitting the passage of smoke from a tobacco column to the filter segment, the total cross-sectional passageway area being from 0.5 to 3 square millimeters, the compound filter having an initial totally...