The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system. ##STR1##

Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.

Compounds of formula I, or a salt thereof or a hydrate thereof, as follows: ##STR1## wherein X and Y are selected independently from hydrogen and aryl, which aryl is unsubstituted or substituted one or more times by hydroxy, hydroxyC.sub.1-6 alkyl, C.sub.1-6 alkoxyC.sub.1-6 alkyl, aryl, heterocyclyl, amino, C.sub.1-6 alkylamino, di(C.sub.1-6 alkyl)amino, arylC.sub.1-6 alkoxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or halo, which alkyl or alkoxy groups are unsubstituted or substituted one or more time...

The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.

The invention provides Response regulator polypeptides and DNA (RNA) encoding Response regulator polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Response regulator polypeptides to screen for antibacterial compounds.

The present invention relates to libraries of compounds based upon a N-(4-alkoxyphenyl)-N-acyl-benzylamine, N-(4-alkoxyphenylmethyl)-N-acyl-benzylamine and N-[2-(4-alkoxyphenyl)ethyl]-N-acyl-benzylamine template, to processes for the preparation of such libraries and their use as a screening tool in biological assays for identifying new chemical leads.

The invention provides compounds of general formula (I) wherein Q, R, R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy ##STR1##

The invention provides compounds of general formula ##STR1## wherein R.sup.1, m, Q, T, n, R.sup.2, R.sup.3, V, W, X and R.sup.4 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

This invention relates to componds of formula I ##STR1## which are useful as PDE IV inhibitors and for treating diseases related thereto.

The invention provides compounds of general formula (I) wherein Q, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.