Compounds of formula I: ##STR00001## wherein A, D, Ar.sup.1, E and Ar.sup.2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain ##STR00001##

Compounds of formula (I) wherein X is O, CH.sub.2, S or NH, or the moiety X--R.sup.1 is hydrogen; V is CH or N; Y is NR.sup.10R.sup.11, NR.sup.10C(Z)NR.sup.10R.sup.11, NR.sup.10COOR.sup.11 or NR.sup.10SO.sub.2R.sup.11; Ar is phenyl or a 5- or 6-membered heteroaryl ring either of which may be optionally substituted; n is 0, 1, 2, 3 or 4; and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.10 and R.sup.11 have the meanings given in the description; and pharmaceutically acceptable salt thereof.

A compound having the general formula ##STR00001## and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.

The invention provides compounds of general formula (I) wherein m, n, Z.sup.1, Z.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined in the specification, process for their preparation, pharmaceutical compositions containing them and their use in therapy.

The invention relates to thienopyridazinones of formula (I): wherein: R.sup.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.3-6 cycloalkyl which is optionally substituted by C.sub.1-6 alkyl, each of the above being optionally substituted by one or more halogen atoms; R.sup.2 is C.sub.1-6 alkyl; R.sup.3 is a group CO--G or SO.sub.2--G where G is a 5- or 6-membered ring containing a nitrogen atom and a second heteroatom selected from oxygen and sulphur adjacent to the nitrogen, and optionally sub...

Compounds of formula I: ##STR00001## wherein A, D, Ar.sup.1, E and Ar.sup.2 are as defined in the specification, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders.

The invention relates to thiophene carboxamides of formula (I), wherein R.sub.1, R.sub.2, R.sub.3, A, n and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy ##STR00001##

The present invention relates to new compounds of formula I, ##STR00001## wherein P, Q, X.sup.1, X.sup.2, X.sup.3, X.sup.4, X.sup.5, R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, G, M.sup.1, M.sup.2, M.sup.3, m and n, are defined as in formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.

The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.