The present invention relates to compounds of formula (I) ##STR00001## and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infections in a human or animal body.

A compound of Formula (I) ##STR00001## and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein R.sup.1 is H, C.sub.1-6alkyl, --C(X)Y, C.sub.3-8cycloalkyl, aryl, het, aryl-C.sub.1-4alkyl or het-C.sub.1-4alkyl, wherein the cycloalkyl, aryl or het groups are optionally substituted by at least one substituent independently selected from C.sub.1-8alkyl, C.sub.1-8alkoxy, OH, halo, CF.sub.3, OCF.sub.3, SCF.sub.3, hydroxy-C.sub.1-6alkyl, C.sub.1-4alkoxy-C.sub.1-6alkyl and C.sub....

The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system ##STR00001##

The novel optically pure compounds Na.sup.+, Mg.sup.2+, Li.sup.+, K.sup.+, Ca.sup.2+ and N.sup.+ (R).sub.4 salts of (+)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H- benzimidazole or (-)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H- benzimidazole, in particular sodium and magnesium salt form thereof, where R is an alkyl with 1-4 carbon atoms, processes for the preparation thereof and pharmaceutical preparations containing the compounds as active ...

A compound having the general formula and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.

Spermine:peptide-based surfactant compounds are disclosed. The compounds are based on a spermine backbone with peptide groups and optionally hydrocarbyl groups linked thereto. Uses of the spermine:peptide-based surfactant compounds and methods for their production are also disclosed.

The present application is directed to compounds having the structure of Formula I: ##STR1## where R.sup.1 is phenyl, pyridinyl, thiophenyl, furanyl, imidazolyl or trazolyl, each optionally substituted by a straight or branched C.sub.1 -C.sub.6 alkyl, NO.sub.2, CF.sub.3, C.sub.1 -C.sub.6 alkoxy, chloro, fluoro, bromo, or iodo; where R.sup.a and R.sup.b are independently selected from hydrogen, a straight or branched C.sub.1 -C.sub.6 alkyl, NO.sub.2, C.sub.1 -C.sub.6 alkoxy, chloro, fluoro, bromo...

##STR1## The invention provides compounds of general formula (I) wherein m, n, Q, Z.sup.1, Z.sup.2, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

A compound of formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is --C(O)Ar.sup.1, --C(R.sup.4)(R.sup.5)Ar.sup.1 or Ar.sup.3 ; R.sup.3 represents a group X--R.sup.10 or Ar.sup.2 ; X represents a bond or a group NR.sup.11 ; and R.sup.10 represents C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl, each of which may be optionally substituted by one or more substituents independently selected from carboxyl, hydroxyl, --C(O)--R.sup.12, C.sub.3-6 cycloalkyl, morpholinyl,...

Compounds of formula (I) wherein R.sup.F1, R.sup.F2, Z, R.sup.1, R.sup.2, Ar, X and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds were prepared. These compounds are useful in therapy, in particular in the management of pain. ##STR00001##