A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and subunits of hyaluronic acid sufficient to facilitate the agent's penetration through the tissue (including scar tissue) at the site to be treated, through the cell membranes into the individua...

Arrangement for interrogating multiple switch conditions employs a single input microprocessor for a plurality of switch elements that are coupled in series with an operating element and a power source. A variable oscillator has a control input and an output coupled to the microprocessor input, providing a periodic signal to the same. A plurality of impedance elements, e.g., resistors, each with a respective value, are coupled between a respective junction between two successive switch elements ...

A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and subunits of hyaluronic acid sufficient to facilitate the agent's penetration through the tissue (including scar tissue) at the site to be treated, through the cell membranes into the individua...

The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5.alpha.-reductase enzymes from 3-oxo-4-oxa and 4-thiasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5.alpha.-reductase enzyme, NADPH. The invention further relates to the isolated inhibitor-cofactor complex.

A method for determining traffic conditions includes: collecting real-time traffic information of a road; calculating a representative speed value for the road by a fuzzy inference, from the collected real-time traffic information and traffic condition factors having an effect on the road; and transmitting the representative speed value to a terminal of a vehicle traveling on the road corresponding to the representative speed value. The representative speed is sensibly determined and reliable in...

Apparatuses are provided which basically comprise a socket which has at least two contiguous passages formed therein which are adapted to receive exposed wire and/or insulated wire. Bonding materials and crimp joints, alone or in combination, are provided to further secure the assemblies. In one embodiment, electrical connection assemblies are provided, which comprise an electrically conductive wire encapsulated by a sheath of insulating material, the insulating sheath having a first end, a firs...

The present invention relates to the use of nimesulide and structurally related compounds in the prevention and/or treatment of neurodegenerative conditions. It is based, at least in part, on the discovery that nimesulide exhibits a neuroprotective effect against .beta.-amyloid induced cell death. Without being bound to any particular theory, it appears that nimesulide inhibits a non-inflammatory mechanism of neurodegeneration.

Process to polymerize olefins comprising contacting, in a polymerization system, olefins having three or more carbon atoms with a catalyst compound, activator, optionally comonomer, and optionally diluent or solvent, at a temperature above the cloud point temperature of the polymerization system and a pressure no lower than 10 MPa below the cloud point pressure of the polymerization system, where the polymerization system comprises any comonomer present, any diluent or solvent present, the polym...

A method of treating and/or preventing allergic and inflammatory conditions of the skin or airway passages in a human in need of such treating and/or preventing which comprises administering to said human an effective amount of a nonsedating antihistamine for such treating and/or preventing while avoiding the side effects associated with other nonsedating antihistamines that bind to the P-glycoprotein pump and/or the organic anion transport polypeptide pump is disclosed.

The present invention is drawn to a novel and newly discovered low molecular weight protein fragments that are degradation products of COMP and have a molecular weight of about 14-33 kilodaltons and polyclonal and monoclonal antibodies to the new COMP fragment and other known COMP fragments of molecular weight 67-80 kDa and 150-250 kDa, and thrombospondin fragments (collectivvly referred to as "ADP") as well as an assay to measure the level of ADP comprising: (1) incubating a body fluid sample, ...