Methods for treating conditions or disorders which can be alleviated by reducing food intake are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist, alone or in conjunction with other compounds or compositions that affect satiety. The methods are useful for treating conditions or disorders, including obesity, Type II diabetes, eating disorders, and insulin-resistance syndrome. The methods are also useful for lowering the plasma glucose level, lower...

Methods and compositions for preventing abuse of dosage forms comprising an opioid analgesic and an aversive agent (e.g., a dye) in an effective amount to deter an abuser from administering a tampered form of the dosage form intravenously, intranasally, and/or orally are revealed.

Methods of analyzing mercury containing samples for inorganic and organomercurial complexes are disclosed. The methods are highly sensitive and are especially suited to samples containing significant amounts of organic matter. Kits and devices for mercury analysis are also disclosed.

A pharmaceutical formulation of the 5HT1-agonist, zolmitriptan, for use in intranasal administration. The formulation is useful in treating migraine and related disorders.

An apparatus for forming and containing a series of waste containing packs successively distributed along a length of flexible tubing is formed of a housing with a top portion displaying an opening to receive waste material therein and of a cassette containing a package of a flexible pleated tubing and so constructed as to enable the tubing to be dispensed therefrom downwardly into the opening. The apparatus includes a tubing pulling device rotatably mounted to the housing and including an attac...

The present invention provides a novel nitrogen-containing heterocyclic compound useful as a phosphodiesterase-4 inhibitor, and a medicament comprising the same. Further, the present invention provides a nitrogen-containing heterocyclic compound represented by the following formula, its salt or hydrates thereof, and a medicament comprising the same. ##STR1##

A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) ##STR1## effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.

The present invention pertains to a process for activating a catalyst composition comprising at least one hydrogenation metal component of Group VI and/or Group VIII of the Periodic Table, and an S-containing organic additive, wherein the catalyst is contacted with hydrogen at a temperature between room temperature and about 600.degree. C., preferably about 100-450.degree. C., and prior to or during the contacting with hydrogen the catalyst is contacted with an organic liquid. Preferably, the co...

Solvent-containing pastes comprising a polyolefin wax component prepared from one or more olefins by catalysis using a single-site catalyst based on a complex of a transition metal from groups 5 to 8 of the Periodic System of the Elements, and use of these pastes.

A mixture is provided comprising (a) at least one of an elastomeric thermoplastic, a non-elastomeric thermoplastic, an elastomeric thermoset and mixtures thereof, excluding polydiorganosiloxane fluids and (b) a polymer having soft polydiorganosiloxane units, hard polyisocyanate residue units, optionally, soft and/or hard organic polyamine residue units and terminal groups. The hard polyisocyanate residue and the hard polyamine residue comprise less than 50% by weight of the polydiorganosiloxane ...