Use of a mono or dicyclic carboxylic or heterocyclic carboxylic acid ester or amide of an alcohol or amine nitrogen as a ring atom in free base form or in acid addition or quaternary ammonium salt form as a 5-HT.sub.3 antagonist in the manufacture of a medicament suitable for the treatment of serotonin induced gastrointestinal disturbances.

A compound of the formula ##STR1## is useful to treat psychotic disorders in humans, especially schizophrenia, and to prevent exacerbations thereof. The compound can be used as a single therapeutic agent or in combination with neuroleptics such as haloperidol.

Novel ring-contracted macrolides which enhance gastrointestinal motility and novel methods and compositions for treating gtastrointestinal disorders in animals with these macrolides and with certain other previously known ring-contracted macrolides are provided.

A dermatological pharmaceutical composition for stimulating hair growth and for the treatment of conditions of the skin selected from the group consisting of (a) benign moles, papillomas and seborrheic keratoses; (b) unsightly freckles, pimples and blemishes; (c) stasis dermatitis; (d) dermal ulcers; and (e) fungal nail infections; and (f) gingival and mucous membrane inflammations; the composition comprising an effective amount of tannic acid, a debriding agent and a pharmaceutically acceptable...

Use of amylin, or variants of amylin, as well as amylin agonists, for the treatment of bone disorders, in particular osteoporosis, Paget's disease, and malignant deposits in bone, bone loss of malignancy or endocrine disorders or autoimmune arthritides or immobility and disuse, and in other conditions where a hypocalcaemic effect is of benefit. Functional peptide fragments of amylin, or a variant of amylin or amylin fragment, are provided as well as a soluble amylin, amylin fragments, or variant...

A method for treating skin disorders in warm-blooded animals, said method comprising administering to said warm-blooded animals an effective amount of an appropriately substituted benzimidazole or benzotriazole which suppresses the metabolism of retinoids. Compositions comprising said compounds and an effective amount of a retinoid.

A method for changing the shape of the cornea of an eye to correct refractive disorders comprises employing laser radiation having a selected wavelength, beam pattern, and beam power profile, and employing this radiation for a selected time duration, wherein the wavelength, beam pattern, beam power profile and time duration are chosen to selectively kill or injure keratocytes and to avoid shrinking the collagen in a selected treatment volume of the cornea which has a posterior boundary which is ...

The invention relates to the use of p-chloro-N-(2-morpholinoethyl)benzamide in the treatment of anxiety disorders, such as, panic disorders, social phobia and obsessive compulsive disorder,

Compositions and use of .gamma.-linolenic acid and related materials with (i) zinc, .beta.-lactam antibiotics or other materials enhancing physiological 1-series PG synthesis and/or (ii) colchicine, Vinca alkaloids or other materials enhancing physiological synthesis of thromboxane A2, for treatment of inflammatory disorders.

A novel method of treating fibrotic disorders in humans comprises the administration of a sufficient quantity of a composition containing a human alpha- or beta-interferon to raise the total concentration of such interferon in the affected tissue area to about 10 to about 4.times.10.sup.7 IU per cubic centimeter. The interferons used can be naturally derived or recombinant DNA-derived. The interferon composition can be administered by any indicated conventional method and can include any pharmac...