The present invention relates to a method for an early stage detection of three specific pregnancy-related disorders: preeclampsia, intrauterine growth retardation and preterm delivery. According to the method, an antigen consisting of a specific human-derived placental soluble protein, known as PP-13, is determined by radioimmunoassay or ELISA. In the radioimmunoassay method, the PP-13 is labelled by a radioactive iodine and the bounded iodine is counted and correlated with standard curves. The...

The invention relates to the use of certain compounds which act as antagonists of 5-hydroxytryptamine (5-HT) at 5-HT.sub.3 receptors for the treatment of cognitive disorders such as attentional and memory deficits and dementia states.

A method for treating habit disorders in a human patient comprising administering to the patient an anti-habitual amount of a pharmaceutically active compound, which results in activation of a brain reward system, e.g., flupenthixol, or esters thereof or pharmaceutically acceptable salts thereof, either alone or in admixture with a physiologically acceptable diluent.

Methods of measuring gastric emptying time comprising providing to a patient a meal comprising a breath test food additive substrate, wherein the substrate is a linear or cyclic acyl aminoacid peptidomimetic that includes a radioactive or non-radioactively labeled carbon atom; having the patient digest the meal so that the carbon labeled nutrients therein are absorbed in the small intestine and metabolized to labeled CO.sub.2 ; and, at periodic intervals, detecting the level of labeled CO.sub.2 ...

A method for preventing loss of bone mineral in mammals which method comprises administering to a mammal an amount of an aminoalkylenephosphonate which is effective to prevent or minimize loss of bone material density. The aminoalkylenephophonates of the present invention should have at least one R-N(Alk-PO.sub.3 H.sub.2).sub.2 group or at least two RRN-Alk-PO.sub.3 H.sub.2 groups wherein R and R can be, same or different, aliphatic or cyclic moiety, and Alk is an alkylene group having from 1 to...

The present invention describes novel compounds of the formula: useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present invention also provides novel compounds useful for monitoring therapeutic angiogenesis treatment and destruction of new angiogenic vasculature. The pharmaceuticals are comprised of a targeting moiety that binds to a receptor that is upregulated during angiogenesis, an optional linking gro...

In general, the present invention provides methods for promoting the function of retinal cells using neuregulins. A novel aspect of the invention involves the use of neuregulins as growth factors tp promote survival of retinal cells. Treating of the retinal cells to provide these effects may be achieved by contacting retinal cells with a polypeptide described herein. The treatments may be provided to slow or halt net cell loss or to increase the amount or quality of retinal tissue present in the...

A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.

The invention relates to a preparation for the treatment of pigmentation disorders. The preparation contains a physiologically active quantity of the DCoH protein, the DNA and/or RNA coding for the protein or DCoH antibodies or antiserum as active ingredient in a pharmaceutically suitable excipient. The invention also relates to the use of DCoH, the DNA and/or RNA coding for same or DCoH antibodies or antiserum as active ingredient in the production of such a preparation.

Benzene derivatives of the formula: ##SPC1## Wherein R.sup.1 represents alkanoyl amino of not more than nine carbon atoms, R.sup.2 represents alkyl of one through six carbon atoms, and R.sup.3 represents alkyl of one through six carbon atoms or cycloalkyl of three through six carbon atoms, possess pharmacodynamic properties and are useful in the treatment of various cardiac disorders.