A novel assay method suitable for screening of novel antipsychotics wherein the drugs may be selected based on the differential internalization of the 5-HT2A receptor in neuronal and non-neuronal cell lines effect for it to predict the extrapyramidal symptoms that may be induced by an antipsychotic without having to carry out in vivo experiments.

Antifertility drug complexes which have enhanced effectiveness and prolonged release of the antifertility drug. The complex includes an antifertility drug, a polybasic acid and a polyvalent metal ion. The antifertility drug is in the form of a basic amine derivative.

An anxiolytic drug of the invention comprises an orexin receptor antagonist, a pharmacologically acceptable salt thereof, or a solvate thereof as an active ingredient. A method for screening a compound having an anxiolytic action of the invention comprises a step of using orexin-A.

An automatic system adapted to store, select for dispensation and count dispensed articles such as controlled drugs especially useful for the storage, dispensing and keeping of accurate, tamper proof records of controlled drugs in hospitals. A novel programmed strip for the system is also disclosed.

Reversible pegylated drugs are provided by derivatization of free functional groups of the drug selected from amino, hydroxyl, mercapto, phosphate and/or carboxyl with groups sensitive to mild basic conditions such as 9-fluorenylmethoxycarbonyl (Fmoc) or 2-sulfo-9-fluorenylmethoxycarbonyl (FMS), to which group a PEG moiety is attached. In these pegylated drugs, the PEG moiety and the drug residue are not linked directly to each other, but rather both residues are linked to different positions of...

A food or drug is prepared to be suitable for treatment of intestinal disorders by adding thereto a composition which comprises microfibrillated cellulose and a water-soluble saccharide.

A bandage for the transdermal or topical administration of a drug over an extended period of time comprising an impermeable backing sheet, a solid drug pellet on the backing sheet, and a layer of contact adhesive covering the pellet and backing sheet. In another form, the adhesive is carried by a web made of a non-woven or woven fabric. Control over the rate of dissolution of the solid drug can be achieved by varying the type of web fabric, the type of adhesive, and the thickness of the adhesive...

Azolylmethylcycloalkanes of the formula I ##STR1## where A and B are identical or different and are each hydrogen, unsubstituted or halogen-substituted alkyl of 1 to 4 carbon atoms, naphthyl, hetaryl, biphenyl or phenyl, where the phenyl radical can be substituted by halogen, nitro, alkyl, alkoxy or haloalkyl, each of 1 to 4 carbon atoms, phenoxy or phenylsulfenyl, D and E are identical or different and are each hydrogen or halogen, Z is CH or N, m can be 1, 2, 3 or 4 and n can be 0, 1 or 2, the...

A thermal fumigator is disclosed which vaporizes a drug in order to fumigate a space. The drug is vaporized by heat generated when the vapors of a volatile fuel come in contact with a metal catalyst. The fumigator includes a fuel container, a metal catalyst and a compressed mat, impregnated with a drug, which are held at fixed distances from each other for maximum efficiency.

To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) ...