The present invention provides for a stent for treatment and prevention of arterial stenosis and re-stenosis. The stent for intraluminal placement within an artery and subsequent expansion for implantation in a patient comprises of a main body portion having a first end and a second end, for defining a passage for flow of blood there-through, the main body portion having an inner lumen surface and an outer lumen surface, the outer lumen surface coming into contact with the endothelium and delive...

The invention provides an excellent novel analgesic which acts on a nociceptin receptor to exhibit a wide range of the analgesic effect for example on a chronic pain as well as an allodynia accompanied with a herpes zoster.The invention relates to a nociceptin receptor agonist comprising as an active ingredient a compound represented by Formula (I) or a salt thereof: ##STR00001## wherein R.sup.1 represents a hydrogen atom or alkyl; A.sup.1 and A.sup.2 are the same or different and each represent...

The object of the present invention is to provide a composition which exerts a higher effect on recovering health from articular disorders than that attained by amino sugars and glycosaminoglycans. The present invention solves the object by providing an agent for treating articular disorders, comprising an amino sugar and trehalose as effective ingredients.

Anticonvulsant compositions comprise as the active ingredient a compound selected from the group consisting of those of the formulae: ##STR1## wherein R.sub.1 is o-chlorophenyl, o-nitrophenyl, 2,4- or 2,6-dichlorophenyl, 4-pyridyl, 2-pyridyl, or 2-quinolyl, and R.sub.2 is hydrogen, m- or p-trifluoromethyl, p-methyl, p-ethyl, m- or p-chloro, m-nitro, p-bromo, p-fluoro or p-COOR.sub.3 wherein R.sub.3 is lower alkyl of 1 to 4 carbon atoms. The compositions are administered to mammals in an amount t...

An oral drug dosage unit, for administration to a patient, having active drug, and an effective diameter and surface composition sufficient for the unit to be transported from the stomach into the duodenum following substantially complete emptying of chyme from the stomach into the intestine and prior to release of active drug from the unit, wherein the active drug has an absorption rate that is substantially affected by the coinciding presence of food in the stomach, the effective diameter of t...

A method and apparatus for introducing a fluid agent into body tissue by causing transport of the fluid agent into the dermis of the subject. The outer surface of the skin of the subject is drawn against a plurality of micropenetrators such that microfissures are cloven into the epidermis and fluid may be introduced for diffusion or suction within the dermis. Suction creates a pressure gradient within the dermis to cause fluid take-up by the dermal tissue. The micropenetrators are produced by pu...

A method of inhibiting human IL-5 gene transcriptions mRNA expression and protein production by human T-cells using one or more compounds selected from those shown by formula I shown below (where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group) and a therapeutic agent for allergic and eosinophilic inflammatory diseases which contains one or more compounds selected from those shown by the formula. ##STR1##

An apparatus and control method for feeding medications in which processing units, which can prepare drugs, non-drug articles and drug-related articles, are provided along a carrier feed line, and in which carriers for respective patients are fed on the feed line in the order in which preparations for carriers, preparations for medications, and preparation for receiving carriers are all finished so that a large amount of medications can be collected and delivered by carts to a plurality of wards...

Bandage for use in the continuous administration of drugs by absorption comprising a backing member bearing a pressure-sensitive adhesive layer on one surface thereof. Distributed throughout the pressure-sensitive adhesive are microcapsules comprised of a systemically active drug encapsulated with a material permeable to passage of the drug. The drug is in a form acceptable for absorption through the skin or the mucosa of the mouth.

Benzimidazole-2-sulfonamide and imidazopyridine-2-sulfonamide derivatives corresponding to the general formula: ##STR1## and their pharmaceutically acceptable salts in which: Z.sup.1 to Z.sup.4 represent a nitrogen atom or a substituted or unsubstituted carbon atom; R.sup.3 represents a hydrogen atom or an alkyl, aryl, heteroaryl, alkylaryl, hydroxyalkyl, alkylheteroaryl, mono-, bi- or tri-cycloalkyl, alkylamino, N-alkyl-alkylamino, alkylcarboxyalkyl, acyl, alkylthioalkyl, alkylsulfinylalkyl or ...