A method of potentiating the activity of a drug which affects the central nervous system. (CNS) comprising systemically administrating to a subject said drug together with an effective amount of a compound which affects peripheral chemoreceptors and, optionally, with an effective amount of a stimulator of osmoreceptors. Also disclosed are pharmaceutical compositions for systemic administration comprising a CNS drug together with the aforementioned compounds.

Bioabsorbable modular drug delivery devices having shapes and sizes adapted to be inserted within a mating receptacle on the surface of an implantable prosthesis are disclosed. The devices may be attached to one another to create custom drug delivery devices having controllable drug release characteristics that depend on the composition of individual modules comprising the device. The modules may be cylinders, disks, tiles or tubes comprised of a bioabsorbable polymer and a therapeutic agent. Th...

A method and composition for potentiating the effects of neuroleptic drugs by administering to a human having a disorder normally treatable with a neuroleptic drug, a neuroleptic drug in combination with a potentiating amount of an amino acid of the formula ##SPC1## Where R is fluorine, chlorine, bromine or trifluoromethyl and their salts.

A syringe package is provided for a syringe including a cylinder having a hypodermic needle projecting through one closed end thereof, the needle extending throughout the major portion of the length of the cylinder and extending from said closed end. A plunger is provided which may be readily secured to the cylinder, and which contains the fluid to be dispensed. The package includes a carton which supports the cylinder and plunger in side-by-side relation. The carton is generally rectangular in ...

An article for dispensing drugs is disclosed which is formed from a biodegradable polymeric material and a drug. The drug is intimately dispersed throughout the polymer and the combination is formed into a solid, shaped article which controllably dispenses the drug.

The invention relates to a compound of the following general formula [I] or a medicinally acceptable salt thereof, or a solvate thereof, ##STR1## wherein R.sup.1 represents alkyl, alkenyl, alkynyl, alkoxy, hydroxy, cyano, or halogen; R.sup.2 represents hydrogen, hydroxy, or halogen; R.sup.3 represents hydrogen, alkyl, or amidino; Ring A represents a 5 to 11-membered cyclic amino group which may be substituted, which cyclic amino group may be bridged between two carbon atoms in optional positions...

A bedside-pharmacy systen for the preparation and delivery of intravenous drugs. The system includes a liquid inlet for connection to a liquid supply, vial receptacles, and a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The system induces ...

Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A--(B).sub.b0--(C).sub.c0--NO.sub.2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R--T.sub.1--, wherein R is the radical of an analgesic drug for the chronic pain, in particular for the neuropathic pain; B is such that its precursor is selected from anminoacids, hydroxyacids, polyalcohols, compounds containing at least one acid function; C is a bivalent radical containing an alip...

A series of imidodisulfamide derivatives encapsulated in liposomes have been prepared and are useful to treat antiviral infections, especially infections caused by orthopox viruses.

The present invention describes a method for programming a specific course and rate of metabolism for a parent drug compound that leads to an inactive or very weakly active and nontoxic metabolite when the modified drug compound is administered. The parent drug compound is modified by forming one or more of a predetermined chemical arrangement within the parent drug structure where the chemical arrangement is A-O-(R)--X--R'; where A is absent or is a tether moiety which allows for a metabolicall...