Novel multibinding compounds are disclosed. The compounds of this invention comprise 2 10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Ca.sup.++ channel, thereby modulating the biological activities thereof.

A method is provided for monitoring a characteristic of a patient, based upon radioactivity, such as the amount of radioactive drug in a patient's system, and automatically attaining and maintaining a predetermined level of drug concentration in the patient, based on such monitoring. The system for carrying out such method includes monitoring means for monitoring radioactivity or level of radioactive drug previously administered to a patient, and administering additional radioactive drug to the ...

Novel compositions comprising dimethylisosorbide solutions of otherwise difficultly soluble muscle relaxant drugs and their applications are described. Additive synergism of muscle relaxant properties of the solvent and solute is disclosed.

An implantable capsule for delivering drugs when subjected to a magnetic force outside the body and controlled by the patient. The capsule has a means movable under a magnetic force to effect contact of the medicament in the capsule with a drug-permeable wall. When contacted, the drug diffuses through the wall into the body. When it is desired to cease drug administration, the capsule is subjected to an opposite magnetic force to seal the permeable wall from contact with the drug.

A method of bioassay including the mating of female and male mice, introducing a test drug into the females within a time which begins before mating and ends within a few days after mating, sacrificing the female at various times within a few days of mating, flushing out the contents of the oviducts and of the uterine horns separately and examining the flushed out contents.

A drug preservation container unit for use in connection with injection. It comprises a vertically elongated casing sealed with a cap and a needle assembly held in an upright position within said casing, said needle assembly containing a freeze-drying-processed drug for use in injection and arranged to be connected to a syringe. The unit contains such drug in such a small quantity as to be conveniently dispensed to a small number of persons. The invention also provides a method of preserving dru...

The present invention relates to new anthracyclines corresponding to the general formula I below: ##STR1## in which R' and R", which may be identical or different, denote a hydrogen atom (and in this case R' is different from R") or the group --(CH.sub.2).sub.n --R.sub.1 --(CH.sub.2).sub.m --R.sub.2 where n is between 1 and 6, m is between 0 and 4 (with the proviso, of course, that if m=0, R.sub.2 is nonexistent) R.sub.1 denotes one of the following groups: ##STR2## (in this case, m=0) ##STR3## ...

A target-entrapped drug comprising three chemically joined components (1) the active drug component; (2) a linking chain; and (3) an activatable group; the activatable group on exposure of the drug to activation liberating components (1) and (2) so that the drug component (1) is bound to a selected target site through the linking chain (2). The drug is administered and then activated by exposure to electromagnetic radiation or other energy such as thermal energy at the anatomic target site.

A method to treat or prevent retroviral infection by administering a novel conjugate is described. Lucifer Yellow and its analogs are conjugated to compounds having carbonyl functional groups for reaction with the semicarbazide moiety of Lucifer Yellow to obtain the semicarbazone conjugate.

Phenylpiperidinylamines of the formula I ##STR1## where R.sup.1 is --NHSO.sub.2 R.sup.4 or ##STR2## R.sup.2 and R.sup.3 are each, independently of one another, H or C.sub.1 -C.sub.4 -alkyl or together are a (CH.sub.2).sub.n chain with n=4 or 5, and R.sup.4 is C.sub.1 -C.sub.4 -alkyl or phenyl, and the physiologically tolerated salts thereof, and pharmaceutical compositions containing these are described.