Carcinostatic composition containing an oily substance such as a glyceride and 3-N-o-toluyl-5-fluorouracil suspended therein. The composition exhibits a remarkable carcinostatic effect against various cancerous cells at a low dose and has less side-effects than 5-fluorouracil and its known derivatives which have been typical carcinostatic compounds. A process of producing carcinostatic composition comprises dispersing 1,3-di-N-acyl-5-fluorouracil into an oily substance such as a glyceride to pre...

The present disclosure relates to a compound of the general formula: ##STR1## and the novel antipodes of that compound.

The present invention provides a non-injection type anti-cancer composiiton comprising a 5-fluorouracil type compound and an oxonic acid or a pharmacologically acceptable salt thereof as effective components, the composition being capable of inhibiting inflammation development due to the 5-fluorouracil type compound, and a method of treating a cancer while inhibiting inflammation development due to the 5-fluorouracil type compound.

The Pt compound may be prepared by reacting the known dichloro(1,2-diaminocyclohexane)platinum(II) (NSC 194814) with silver nitrate to replace chloro with nitro. Subsequently, benzene tricarboxylic acid is added to form an off-white precipitate (2 hrs, dark, 5.degree. C.) of the desired product which is preferably utilized as the alkali metal salt. The 4-carboxyphthalato(1,2-diaminocyclohexane)platinum(II) and alkali metal salts thereof may be combined in multiple drug regimen with substantially...