Solvent systems for enhancing the solubility of ibuprofen for encapsulation into soft gelatin capsules is provided by the addition of ammonium acetate to the solvent system.

A therapeutic taste-neutral powder form of ibuprofen obtained by spray-drying a suspension of colloidal silica in a lower alkanol solution of ibuprofen and cellulose acetate phthalate.

A process is disclosed for the formation and resolution of (S)-ibuprofen-(S)-lysine. The process employs preferential crystallization to separate a pair of diasteromeric salts, (S)-ibuprofen-(S)-lysine and (R)-ibuprofen-(S)-lysine.

A liquid water base ibuprofen composition for oral administration is described, the ibuprofen being maintained in suspension by a combination of primary suspending agents and being taste masked by primary taste masking agents, the composition also containing a buffer acid to adjust the pH of the composition to between 1.5 and up to about 3.5 and to provide a buffer capacity within the range of 0.03 to 0.05 between the initial pH and a pH which is 1.0 pH unit higher than the initial pH.

A method is provided for the preparation of ibuprofen by carbonylating 1-(4'-isobutylphenyl)ethanol (IBPE) with carbon monoxide in an acidic aqueous medium, e.g. containing at least 10% of water based on the weight of IBPE initially added, at a temperature of at least about 10.degree. C. and a carbon monoxide pressure of at least about 500 psig, and in the presence of (1) a catalyst complex consisting essentially of a palladium compound in which the palladium has a valence of zero to 2 and is co...

Ibuprofen is isolated from tablets or other solids by dissolving the ibuprofen in an alkane or cycloalkane solvent, filtering off undissolved solid, and stripping the solvent from the ibuprofen by evaporation or by recrystallization at low temperatures.

This invention relates to a pharmaceutical composition for use in the treatment of pain and inflammation and the treatment of acid indigestion, sour stomach, heartburn and symptoms of upset stomach associated with these conditions in a mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatory effective amount of (S)-ibuprofen, or a salt thereof, substantially free of (R)-ibuprofen; (ii) an amount effective in the treatment of acid indigestion, sour stomach and/o...

The unpleasant taste of water-soluble ibuprofen salts in aqueous solution is masked by incorporating in the solution a taste-masking amount of an alkali metal bicarbonate, alkali metal monohydrogen phosphate or alkali metal tribasic citrate. Preferably, the taste-masking compound is an alkali metal bicarbonate, especially sodium bicarbonate.

This invention relates to pharmaceutical compositions for use in the treatment of pain and inflammation and the treatment of muscle spasms and associated pain, soreness and tightness of muscles in mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatory effective amount of (S)-ibuprofen, or a salt thereof, substantially free of (R)-ibuprofen; and (ii) an amount effective in the treatment of muscle spasms of at least one of the muscle relaxants, or a therapeutic...

The present invention relates to pharmaceutically acceptable and stable compositions, which are preferably clear transparent, for liquid filling hard shell capsules, hard shell capsules containing these compositions, and a process for preparing these hard shell capsules and whereby the shells of said hard capsules are preferably clear transparent.