The present invention relates to a method of identifying a molecule of a molecule-substrate complex, wherein the molecule is covalently attached directly to a substrate or indirectly by means of a linking moiety, comprising: (a) bombarding the molecule-substrate complex with energized particles to cleave the molecule from the molecule-substrate complex; and (b) determining the molecular weight of the cleaved molecule by means of mass spectrometry. The inventive method may further comprise irradi...

Method for treatment of a disease in a patient characterized by accumulation of .beta.-amyloid. The method includes identifying a patient potentially suffering from such a disease and contacting a neuron of the patient with a therapeutically effective amount of a tachykinin agonist. Methods for screening for compounds useful for treating such a disease are also disclosed.

A method and system for identifying a defocus wafer by mapping a topography of each wafer in a first wafer batch using a level sensor apparatus (100); calculating a focus spot deviation (402) from the data, the focus spot deviation (402) corresponding to a height by which a focus spot of a photo exposure module would be defocused by the topography; converting the focus spot deviation (402) to a corresponding wafer stage set point to which the photo exposure module is set, to focus the focus spot...

A wire detector for determining the designation of a wire in a random bundle of wires which are connected at a first end to a group of designatory points, comprising connection means between said group of designatory points and a display device; a probe for contacting the second end of a wire in said bundle; said probe being coupled to said display device to complete a circuit through the selected wire, which causes the display device to indicate the designation thereof by displaying a predesign...

This invention provides a method of identifying a tumor suppressor gene of a cell(s). Analogous methods to identify tumor suppressors in normal cells and to identify genes associated with unknown genetic defects are also described. The feasibility of the title method was demonstrated by observing the effects of caffeine acid phenethyl ester on oncogene-tranformed CREF cells. In a second series of expts., human papillomavirus 18-transformed CREF cells were transfected with human fibroblast cDNA c...

The present invention relates to methods for identifying a compound capable of modulating mitochondrial function, comprising contacting a eukaryotic cell with one or more candidate compounds, and detecting a change in the mitochondrial redox state of the cell. The methods further relates to such methods wherein endogenous fluorescence of the cell mitochondria is indicative of a change of redox state.

A method for identifying and/or differentiating between asbestos materials and aramid materials comprises the steps of rubbing an area of a surface of a material (44) to be identified, with an acrylic reference material (28), measuring the polarity of the generated electrostatic charge and comparing the polarity with polarities of charge generated from surfaces of known asbestos and aramid materials.

The invention provides a method for preparation of probes for use in detecting enteroinvasive Escherichia coli and Shigella species. The small probes provide reliable and inexpensive means for detecting the pathogens in food samples and in environmental and clinical samples.

Provided are methods to detect of modulators of the Receptor for Advanced Glycated Endproducts (RAGE). The invention comprises a method for detection of RAGE modulators comprising: adsorbing a RAGE ligand onto a solid surface; adding a compound of interest and a protein comprising RAGE or fragment thereof, to the preadsorbed ligand; adding an antibody which binds to RAGE or fragment thereof and a secondary antibody which binds to the anti-RAGE antibody; measuring the secondary antibody bound to ...

A system, method, and device for identifying data sources for a neural network are disclosed. The exemplary system may have a module for determining load curves for each selected data set. The system may also have a module for determining a global difference measure and a global similarity measure for each load curve of each selected data set. The system may have a module for determining a set of data sets with lowest value global difference measure. The system may also have a module for determi...