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A pentapeptide of the formula: wherein A, B, D are the same or different amino acid residues selected from the group consisting of Phe, Phe(4-Cl, Phe(4-F), Phe(4-Br), Phe(OMe), Tyr, Phe (4-I) and Tyr (ortho-Me); C is Val, threo-.alpha.-amino-3-chlorobutyric acid, or Thr; E is lysine or arginine; X is NH.sub.2, NHR, wherein R is C.sub.1 -C.sub.4 alkyl, OH, OR.sup.1, wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl, or OM, where M is a physiologically acceptable cation or addition salts of said pentapept...
The degradation of enkephalins in a mammalian host is inhibited by administration of an enkephalinase enzyme inhibitor of the formula ##STR1##
Corrosion inhibition of metals is obtained treating a system with a corrosion-inhibiting amount, preferably 1 to 10000 ppm, of an optionally-substituted .beta.-pyridyl-ethylamine or a salt thereof, which may be prepared by reacting an amine with a vinylpyridine, preferably in the presence of an acidic catalyst such as acetic acid. The .beta.-pyridyl-ethylamine is a compound of the general formula: ##STR1## wherein R is an alkyl, aryl, aralkyl, alkaryl, halo or amino group of a group --COX where ...
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit lipoxygenase, thus preventing the metabolism of arachidonic acid to the leukotrienes. These compounds are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.
The degradation of enkephalins in a mammalian host is inhibited by administration of an enkephalinase enzyme inhibitor of the formula ##STR1##
This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and thereby preventing or retarding the disease states caused by said degradation by administering compounds of the formula: ##STR1## or their pharmacologically acceptable salts.
A compound of the formula wherein the Xs are the same or different and selected from the group consisting of an aromatic, a chlorinated aromatic, an aliphatic and a chlorinated aliphatic amino acid residue; Y is a positively or negatively charged amino acid residue; and Z is a proline or a polyprolyl residue having up to 5 prolyl residues, is useful for decreasing renin-related high blood pressure.
A series of novel water-dispersible corrosion inhibiting solutions are disclosed which contain a composition which includes the reaction product of an amine mixture and an organic monomer acid mixture. A process for the inhibition of corrosion in aqueous environment is also disclosed. The process is particularly useful for protecting metal surfaces in subterranean petroleum pumping wells.
Furfural or derivatives thereof, especially 5-chloromethyl furfural, is inhibited against the formation of resinous decomposition products by addition of epoxy compounds such as the reaction product of epichlorohydrin and bisphenol A.
Corrosion and scale-inhibiting compositions which are useful in recirculating aqueous systems comprise a mixture of a phosphate compound, a phosphonate compound comprising 1-hydroxyethylidene-1,1-diphosphonic acid or nitrilotris(methylene)triphosphonic acid, an aryl triazole, and a salt of a metal selected from the group consisting of molybdenum, tungsten and chromium. In the preferred embodiment of the invention, the phosphate compound is present in a weight percent ratio in the range of from a...
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