Human basement membrane matrix is provided, produced by a novel tumorigenic cell line, where the basement membrane can be used for the growth of a variety of cells, in culture and in vivo. Other cell lines are provided, which may serve to evaluate in vivo the response of tumorigenic cells to various agents, including basement membrane. The basement membrane finds use in allowing the growth of cells in culture and in vivo, particularly cells which are otherwise refractory to xenografting.

In a method of developing muscle mass in a mammal, nicotine or nicotine acetylcholine receptor agonist (nAChR) is administered in combination with exercise to stimulate, recruit and mobilize muscle cells to a specific muscle mass.

An object of the present invention is to provide a model animal of Parkinson's disease comprising an .alpha.-synuclein gene introduced therein. The present invention provides a transgenic non-human mammal or a portion thereof, wherein an .alpha.-synuclein gene is introduced and the gene is expressed in neurons, and the number of dopamine-producing neurons in the substantial nigra is significantly decreased as compared with that of a wild-type animal.

The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins.

A method for producing a recombinant mammal in vivo is disclosed. The mammal has a mammary gland, with mammary epithelial cells lining a duct in that gland One increases the rate of mitosis of the mammary epithelial cells (e.g. by using perphenazine or a mitogen), and one then exposes the mammary epithelial cells in vivo in the gland to a recombinant vector (e.g. a retrovirus vector). The mammary epithelial cells can be pretreated (or simultaneously treated) with polybrene to facilitate infectio...

A tool holder of general applicability has a molded rubber construction to rictionally engage the nose of the user. Spaced apertures in the tool holder permit attachment of tools and other apparatus thereto as well as permitting normal breathing of the wearer.

The invention is a method of treating endotoxic shock in a mammal which comprises administering to the mammal a therapeutically effective amount of an antagonist to Platelet Activating Factor in combination with a therapeutically effective amount of one or more monoclonal or polyclonal antibodies directed towards either Tumor Necrosis Factor .alpha., Interleukin-1.beta., Gamma Interferon, or bacterial cell wall lipopolysaccharides.

A tooth sensitivity treating composition containing hydroxyethyl methacrylate, sodium fluoride, anti,icrobial compound and an inert solvent, with an antidegenerate preserative.

It has been found that agents which inhibit the interaction between the band 3 protein and its ligand (hereafter sometimes referred to as "interaction inhibitors" or "inhibitors"), CD36/thrombospondin, can also be used to enhance thrombolysis. The inhibitors can be peptides which contain sequences present in exofacial loops of the band 3 protein, or can be non-natural, D-isomer forms of the same sequences, or can be peptides, peptidomimetics, or non-peptidic molecules which interfere with band 3...

Methods are presented for improving the lipoprotein cholesterol profile of a mammal. Methods are also presented for reducing or removing atherosclerotic lesions from a mammal that has such lesions. The methods comprise administering to the mammal a therapeutic amount of an M-CSF protein in combination with a pharmaceutically acceptable excipient.