The invention is a method of treating endotoxic shock in a mammal which comprises administering to the mammal a therapeutically effective amount of an antagonist to Platelet Activating Factor in combination with a therapeutically effective amount of one or more monoclonal or polyclonal antibodies directed toward either Tumor Necrosis Factor .alpha., Interleukin-1.beta., Gamma Interferon, or bacterial cell wall lipopolysaccharides.

A novel method for treating undesired hyperproliferative tissue in a mammal. The method includes the steps of: injecting the mammal with a photodynamic compound having a selective uptake in the hyperproliferative tissue and which is activated at a particular light frequency; injecting the mammal with a xanthenone-4-acetic acid or a Group I metal, Group II metal or quaternary salt thereof near the time of maximum uptake of the photodynamic compound in the hyperproliferative tissue; and exposing t...

A hemofiltration system and method to treat an Inflammatory Mediator Related Disease in a mammal, including chronic and acute diseases, include a hemofilter and an adsorptive device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorptive device may include one or more adsorbent materials and may be used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilt...

This invention relates to methods for lowering lipid levels in mammals using compounds that inhibit advanced glycation endproducts (AGEs), LR-9, LR-74 and LR-90. These compounds, which inhibit non-enzymatic protein glycation, also inhibit the formation of advanced lipoxidation endproducts (ALEs) on target proteins by trapping intermediates in glycoxidation and lopoxidation and inhibiting oxidation reactions important in the formation of AGEs and ALEs.

A method is provided to quantify and/or qualify psychological and physiological components of stress in mammals, in which a stimulus can be applied to the test subject's environment during the test. The method involves the steps of measuring one or more physiological and/or psychological characteristics before and after the administration of a stimulus to a test subject. The stimulus may consist of any product, task, aroma or the like that elicits a stress-related response upon administration. B...

A composition comprising a plurality of microcapsules suitable for parenteral injection into a mammal comprising a plasminogen activator-containing core, and a semi-permeable biocompatible layer surrounding the core permitting controlled release of at least a portion of the plasminogen activator. A method of reducing the time required for reperfusion of an artery containing a thrombus and a method to reduce the standard dosage requirement of a plasminogen activator in a mammal comprising intrave...

A method is provided to quantify and/or qualify psychological and physiological components of stress in mammals, in which a stimulus can be applied to the test subject's environment during the test. The method involves the steps of measuring one or more physiological and/or psychological characteristics before and after the administration of a stimulus to a test subject. The stimulus may consist of any product, task, aroma or the like that elicits a stress-related response upon administration. B...

A method of adjusting the circadian rhythm of a mammal comprising administering to said an effective circadian rhythm adjusting amount of 6-methyl-5-oxo-3-thiomorpholinylcarbonyl-L-histidyl-L-prolinamide or a pharmaceutically acceptable salt thereof is disclosed. The method of the invention may be useful to assist shift workers adjust to rotating work schedules, to alleviate the effects of jet-lag on travelers to remote time zones and/or to treat sufferers of delayed sleep phase syndrome.

The present invention is based in part upon the discovery that the use of pyruvate in enteral formulations, in combination with an anabolic protein composition, produces a synergistic effect in increasing the lean body mass or muscle tissue of a mammal consuming same. The present invention also provides a method for enhanced endurance of athletes. The present invention relates generally to a composition for enhancing the protein concentration or muscle mass of a mammal and a method for enhancing...

This invention relates to the production of recombinant proteins, such as coagulation factors VIII and IX, tissue plasminogen activator (TPA), urokinase, growth hormone, insulin, interferons, interleukins, peptide hormones and immunoglobulins, in mammals' milk. Particularly, this invention relates to an expression system which when transgenically incorporated into a mammal permits the female species of that mammal to produce the desired recombinant protein in or along with its milk. This inventi...