The invention features a transgenic mammal encoding a chimeric ornithine decarboxylase gene, which transgenic mammal exhibits phenotypic abnormalities. The invention also includes a chimeric transgene comprising ornithine decarboxylase.

A recovery system for attaching a line to an underwater object includes a cially worn tool holder adapted to be carried by an underwater mammal which supports a surface engaging tool at the forward end thereof. A signalling mechanism is also included to be actuated on attachment of a tool to an underwater object.

The present invention is based in part upon the discovery that the use of pyruvate in enteral formulations, in combination with anaerobic exercise produces a synergistic effect in increasing the amount of lean body mass or muscle tissue in a mammal. The present invention relates generally to a composition for enhancing the protein concentration or muscle mass of a mammal and a method for enhancing the protein concentration or muscle mass in a mammal. More specifically, the present invention rela...

A new class of arylsulfonylcarbamoyl-1,3-cyclohexanediones and arylsulfonylcarbamoyl-1,3-dicarbonylacyclic compounds are disclosed. These substances have hypoglycemic or hyperglycemic properties and are of value in controlling abnormal blood sugar levels. The arylsulfonylcarbamoyl derivatives of 1,3-dicarbonylalicyclic and acyclic compounds are prepared by reacting an arylsulfonylisocyanate with a 1,3-dicarbonylalicyclic or acyclic reactant. Typical embodiments are 2-(N-p-chlorobenzenesulfonylca...

An attachment and recovery tool for recovery of underwater objects has two elescopically extending arms which together with a central portion encircles the object to be recovered. The telescopically extending arms are urged into object engaging position by spring motor means mounted on the central portion. Latch units mounted on each telescopic arm secure them in encircling engagement with the object to be recovered. Cable means carried by said latch means cooperate with a lifting line to raise ...

There is disclosed a method of testing a cellular hematologic fluid derived from a mammal to determine the existence in the mammal of a pathological state or condition wherein an immunomodulator is admixed with the cellular hematologic fluid of the mammal and a reaction parameter determined and compared with known reaction parameters of cellular hematologic fluids of mammals of known healthy states to like immunomodulator. In a preferred embodiment of the present invention, the reaction paramete...

The invention relates to compositions, methods, apparatus, and kits for alleviating or preventing vasoconstriction or vasospasm in a mammal. The compositions, methods, apparatus, and kits are also useful for alleviating or preventing ischemic tissue damage resulting from ischemia associated with cerebral vasoconstriction which follows aneurysmal subarachnoid hemorrhage, with embolic stroke, with coronary artery obstruction, and with other conditions. These compositions, methods, apparatus, and k...

2-alkyl-5,6 alkylenedioxyindenes and indane-1-di- or tri- alkylammonium salts are useful as calcium antagonists, for example in arrhythmia. The compounds are prepared from the known corresponding 2,5,6-substituted indene-1-1dimethylammonium salts by alkylation and/or hydrogenation.

A method of testing a cellular hematologic fluid derived from a mammal to determine the existence in the mammal of a pathological state or condition wherein an immunomodulator is admixed with the cellular hematologic fluid of the mammal and a reaction parameter determined and compared with known reaction parameters of cellular hematologic fluids of mammals of known healthy states to like immunomodulator. In a preferred embodiment of the present invention, the reaction parameter is a clotting par...

4-[(.alpha.-Methyl)-2,3-dimethyl-benzyl]imidazole is useful as a veterinary sedative-analgetic agent, especially in small mammals.