Polynucleotide sequences, comprising DNA and RNA molecules can be directly administered, for example by injection, to tissues, such as muscle, and expressed as a protein, polypeptide or polypeptide. The polynucleotides can be contained within liposomes or the polynucleotides can free from association with transfection-facilitating proteins, viral particles, liposomal formulations, charged lipids and calcium phosphate precipitating agents.

A method for increasing the hematocrit of a normal mammal using erythropoietin (EPO) is provided. The method comprises the steps of administering to the mammal a hematocrit increasing effective amount of EPO, in a pharmaceutically acceptable form. Additionally administered is an effective amount of iron, in a pharmaceutically acceptable form, sufficient to increase the serum iron content of the mammal to an erythropoiesis supportable level. The method is useful for increasing the amount of blood...

A water based photosensitive composition comprises a hydrolyzate of a mammal collagen and a photosensitizer serving to cross-link the hydrolyzate when exposed to an active light. The hydrolyzate has a number-average molecular weight, Mn, of 2,000 to 30,000 and an intrinsic viscosity, [.eta.], of 0.060 to 0.155 dl/g in a 0.15 mole citric acid buffer solution maintained at 40.degree.C. Also, the hydrolyzate is capable of maintaining the formability of the collagen fold. A photoresist pattern forme...

The present invention relates to a novel method for testing the developmental status in pancreatic cells of a mammal. The present invention further relates to applications in the medical field that directly arise from the method of the invention. Additionally, the present invention relates to transgenic mammals comprising at least one inactivated Pax4 allele and optionally at least one inactivated Pax6 allele.

A composition comprising a mixture of fatty acids such as oleic, palmitic and linoleic acids and derivatives thereof which are used for enhancing weight gain in a mammal. Methods to enhance weight gain using the fatty acid compositions are also described.

Methods and devices for manipulating the thermoregulatory status of a mammal are provided. In the subject methods, thermal energy is transferred between the environment and both the thoracic/abdominal core body and head of the mammal. In general, such thermal energy transfer occurs under negative pressure conditions. The subject methods and devices find use in a variety of applications.

A vivarium specifically designed for rehabilitating an aquatic fur-bearing mammal or bird, particularly a sea otter, includes an improved enclosure having large outwardly flared ports covered with soft flexible netting, curved and rounded joints, corners and edges, and surfaces which are smooth and projectionless. An improved swimming environment is sized to allow rehabilitative grooming behavior and an improved dry environment has weight bearing surfaces that do not focus pressure on discrete a...

A method and a system to provide images of the internal anatomy of a mammal wherein first images of a selected one of body cavities of the mammal are provided by externally generated tomography slice data employing existing tomography techniques, wherein second images are provided by a unique endoscope inserted into the selected one of the body cavities, and wherein the first and second images are correlated to generate composite images of the selected one of the body cavities in real time, in l...

A mammal intestinal hormone precursor having the following peptide structure: His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-L-M-Ala-Arg-Leu-Gl n -Arg-Leu-Leu-Gln-Gly-Leu-Val-Gly-N-O, wherein L is Glu or Asp, M is Gly or Ser, and N and O are selected from Lys and Arg; compositions containing such precursor and a method of stimulating pancreatic secretion.

Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.