The invention provides a method of attenuating lung capillary leak in a mammal by administering an effective amount of an antifolate, methotrexate.

The invention relates to a CHO cell-line capable of producing antibody, the cell-line having been co-transfected with a vector capable of expressing the light chain of the antibody and a vector capable of expressing the heavy chain of the antibody wherein the vectors contain independently selectable markers; also included is a CHO cell-line capable of producing a human antibody or an altered antibody, the cell-line having been transfected with a vector capable of expressing the light chain of th...

A device useful in training marine mammals is disclosed as having an inflatable bladder which, when inflated, increases the hydrodynamic drag and buoyancy of the marine mammal. The device is characterized by having an inactive position having low hydrodynamic drag and negative buoyancy and an activated position which has a relatively high hydrodynamic drag and positive buoyancy. A source of gas under pressure, for example a gas cartridge, is connected so as to inflate the bladder means upon a pr...

Mammals are anesthetized by administration of 2-arylalkyloxy benzamides. When administered, the 2-arylalkyloxy benzamides of this invention are useful for the production of anesthesia, such as local anesthesia, in mammals. When administered intramuscularly, compounds of this invention show significant anesthesia when compared with xylocaine. Again, intradermic injections of 0.2 ml. of a solution of such a compound in concentrations varying from 0.1 to 1.25 mg./ml. effect suppression of platysma ...

Cephalosporin compounds having 2-(2-aminothiazol-4-yl)-2{(1S)-carboxyethoxyimino}acetyl group on the side chain at the 7-position thereof and 1-ethylpyridinium-4-ylthiomethyl group on the side chain at the 3-position thereof or non-toxic salts thereof are excellent antibacterial agents for mammals including human. The cephalosporin derivatives have low toxicity.

A method of treating mammal semen for use in artificial insemination is provided. Human saliva is added to the semen as an anti-coagulant. For mammals other than primates and voles, sperm-free human semen is added to the mammal semen as a cell membrane diffusion material so that a dye such as quinicrine or quinicrine mustard will be absorbed by the Y chromosome. The semen is then fed in a narrow stream through a detection chamber where it is irradiated with ultraviolet light causing the Y chromo...

2-alkyl-5,6-dialkoxy (or 5,6 alkylenedioxy) indenes and indane-1-di- or trialkylammonium salts are useful as calcium antagonists, for example in arrhythmia. The compounds are prepared from the known corresponding 2,5,6-substituted indene-1-dimethylammonium salts by alkylation and/or hydrogenation.

A method and composition for a rectally administered hypoglycemic agent into the bloodstream for the treatment of diabetes in mammals. The hypoglycemic agent is mixed with a physiological surface active agent which results in a suspension. This suspension is then mixed with a dispersion formed by dissolving MYRJ.sup..TM. 45, MYRJ.sup..TM. 51, ONESTA HARDENER.sup..TM. and COTMAR.sup..TM. in ether. This mixture is then evaporated and a semisolid mass results which is then shaped into a suppository...

Mammals are anesthetized by administration of 2-arylalkyloxy benzamides. When administered, the 2-arylalkyloxy benzamides of this invention are useful for the production of anesthesia, such as local anesthesia, in mammals. When administered intramuscularly, compounds of this invention show significant anesthesia when compared with xylocaine. Again, intradermic injections of 0.2 ml. of a solution of such a compound in concentrations varying from 0.1 to 1.25 mg./ml. effect suppression of platysma ...

Drugs, nutrients and other solutes are administered to fixed and mobile tissue cells of the mammal in an aqueous solution containing about 75-200 mM/L of Na.sup.+ , about 7-75 mM/L K.sup.+ , about 12-28 mM/L HCO.sub.3 .sup.- , about 70-195 mM/L Cl.sup.- and preferably containing about 3-8 mM/L Mg.sup.+.sup.+ and about 3-8 mM/L HPO.sub.4 .sup.= and/or SO.sub.4 .sup.= , and/or acetate, and/or gluconate.sup.- ; the solution having a pH of about 7.4 to 8.4 and an osmolality of about 170-460, prefera...