Disclosed herein are carbonyl compounds of Formula I as described herein. ##STR00001## Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the ...

Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered fo...

The invention relates to a control device for monocyclic pitch in a fixed reference system and multicyclic pitch in a rotating reference system, for the blades (7) of a rotor craft. In addition to conventional swashplates (27, 38), one (38) of which rotates (39) on the other (27) held in rotation by a nonrotating compass (28), but which slides axially (4) and oscillates (25) about the rotor mast (1), through the action of pilot control (30), it comprises multicyclic jacks (45) in a number equal ...