Disclosed herein is a nucleic acid-containing glycoprotein having molecular weight of 5,000 to 300,000 as determined by ultracentrifugal method; the weight ratio of protein moiety thereof determined by Lowry-Folin's method to saccharide moiety thereof determined by phenol-sulfuric acid method of in the range of 50/50 to 80/20; N-terminal amino acid thereof consisting essentially of tyrosine, leucine or alanine; leucine-phenylalanine-valine as amino acid sequence at C-terminal thereof; the elemen...

A process for the chromatographic separation of nucleic acid using a chromatographic carrier material is described in which the surface of the carrier material is specially modified.

This invention provides a method of detecting nucleic acid molecules employing cRNA probes in a pre-electrophoretic hybridization procedure. In addition to detecting the presence of nucleic acids an additional embodiment of the invention permits a determination of the size of said nucleic acids to be made.

The present invention is directed to a process for amplifying any desired specific nucleic acid sequence contained in a nucleic acid or mixture thereof. The process comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers, and extending the primers to form complementary primer extension products which act as templates for synthesizing the desired nucleic acid sequence. The steps of the reaction may be carried out stepwise or simulta...

An integrated plate structure provides a novel component for use in an electrophoretic sequencing cell. The integrated plate structure consists of a glass plate and a plastic plate bonded together along a raised edge of the latter, the edge extending along the sides and bottom of the plastic plate. The plates thus form a permanent enclosure for an upper buffer solution, open at the top for filling. The glass plate further serves as one of the two glass plates forming the gel enclosure.

Complex substances capable of enhancing the production of antibodies when introduced in conjunction with an antigen into an animal host are produced by reacting single-stranded or multi-stranded nucleic acid polymers with cationically charged polymers having a molecular weight between about 10.sup.3 and 10.sup.8 in specified proportions, e.g., 50 parts of nucleic acid polymer to 1 part to 500 parts cationic polymer by weight.

Synthetic nacreous pigments comprise at least one thin plate-shaped crystal having a length of 3 to 100 microns, a width of 1 to 40 microns and a thickness of 0.05 to 3 microns, said individual crystal being composed of one nucleic compound selected from the group consisting of nucleic bases, nucleosides and nucleotides. The pigments are non--toxic, have a strong resistance to chemicals, and thus are applicable to cosmetics or decoration of the surfaces of toys and tablewares, or food itself or ...

A process performed upon yeast cells to produce inexpensive, palatable protein by first heat shocking at preselected temperatures, then incubating at other preselected temperatures, under controlled pH and for prescribed intervals of time.

Nucleic acid hybridization probes having at least one nucleic acid strand which has at least two separate target specific regions that hybridize to a target nucleic acid sequence, and at least two distinct arm regions that do not hybridize with the target nucleic acid but possess complementary regions that are capable of hybridizing with one another. These regions are designed such that, under appropriate hybridization conditions, the complementary arm regions will not hybridize to one another i...

A triple-stranded nucleic acid having a first nucleic acid strand that has a region of adjacent purine nucleoside residues; a second nucleic acid strand, at least a portion of which is hydrogen bonded in a Watson-Crick manner to the region of adjacent purine nucleoside residues of the first strand; and a third nucleic acid strand, at least a portion of which is hydrogen bonded to the portion of the region of adjacent purine nucleoside residues of the first strand, the portion of the region of ad...