A process for preparing aromatic bisphenols, wherein the method comprises reacting an aromatic hydroxy compound with an alkylating agent having a functionality of two in the presence of a catalyst system. The catalyst system used for the process is selected from the group consisting of a heteropolyacid compound, a clay, a functionalized metal oxide catalyst and combinations of the foregoing.

The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetate is prepared in high yield and purity by the reaction of a haloacetate with the reaction product of thiourea and benzhydrol. The reaction employing the haloacetate is conducted in a solvent comprising an organic solvent such as methanol having dissolved therein an organic base or an inorganic basic salt such as sodium bicarbonate. The resulting benzhydrylthioacetate can be amidated and t...

Disclosed is a new process and intermediates for preparing benzazepines of Formula (I): ##STR00001## wherein R.sup.1 and R.sup.2 are as defined herein.

A process for preparing peroxidic perfluoropolyethers having a peroxidic content (PO) higher than 1.2 of formula A-CF.sub.2O(CF.sub.2CF.sub.2O).sup.m(CF.sub.2O).sub.n--(CF.sub.2CF.sub.2O- O).sup.ml(CF.sub.2OO).sub.nlCF.sub.2--B (I) wherein A, B, equal to or different from each other are Cl--, F--, ClCF.sup.2--, COF--, --OCOF, --CF.sub.3, m, ml, n, nl are integers such that the (m+ml)/(n+nl) ratio is between 0.9 and 5 and the m/n ratio is between 0.8 and 3, the number average molecular weight is ...

Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A "virtual" oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the sele...

A process for preparing a mixture of copper phthalocyanine dyes of Formula (1): CuPc(SO.sub.3M).sub.x(SO.sub.2NH.sub.2).sub.y, wherein: CuPc is copper phthalocyanine; M is a cation; x and y each independently have a value of from 0.5 to 3.5; and (x+y)=2 to 5; which process includes: chlorosulphonating a copper phthalocyanine compound using a chlorosulphonating agent; and condensing the product of step (i) with ammonia to give a mixture of copper phthalocyanine dyes of Formula (1); optionally exc...

A process for preparing a dibenzothiazepine derivative such as dibenzo[b,f][1,4]thiazepin-11-one employable as a starting material for the preparation of 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperadinyldibenzothiazepine derivative which is known to be effective as an antipsychotic pharmaceutical, has the steps of reacting a nitrobenzene derivative with a thiosalicylic acid derivative, reducing the obtained 2-nitro-2'-carboxy-diphenylsulfide derivative, and subjecting the obtained 2-amino-2'-carbo...

It is to provide an improved method for preparation of microsphere from an emulsion wherein an organic phase containing an organic solvent having a boiling point lower than that of water and a hardly-water-soluble polymer is emulsified in an aqueous phase by an in-water drying method, which comprises: (1) using an apparatus equipped with a gas separation membrane; (2) supplying the emulsion to be subjected to in-water drying to one side of said gas separation membrane; (3) evaporating off the or...

The present invention provides a process for preparing 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (Imiquimod) of formula (I).The process comprises heating 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline of formula (II) with formamide, and optionally with bubbling of gaseous ammonia to afford Imiquimod of formula (I).According to the present invention, by using this process and novel purification methods, essentially as described herein, highly pure Imiquimod is obtained.

A method is provided for bonding substrates using a prepolymer composition that is cured with electron beam radiation. The prepolymer composition provided for bonding the substrates contains at least one polyester resin and at least one polymerizable compound.