Ethylene/propylene random copolymers are formed by reacting a minor amount of ethylene and a major amount of propylene in the reactor in the presence of hydrogen and a diethyl aluminum chloride and a cocrystallized TiC1.sub.3 .sup.. A1C1.sub.3 catalyst under a pressure of from about 200 to about 500 p.s.i.g. which is sufficient to maintain at least part of the propylene in the liquid phase in the reactor.

A new process for the preparation of 4-(4-pyridinyl)benzoic acid, or a salt thereof.

An improved process for preparing steriods, such as 3-oxo-4-azasteroids, is described. Compounds of this type are known to be useful in the preparation of compounds having 5a-reductase inhibitor activity. The process comprises the hydrogenation of the corresponding steroid alkene in the presence of ammonium acetate, ammonium formate, and/or ammonium propionate and an appropriate catalyst.

The present invention relates to a novel process for the preparation of the magnesium salt of the (-)-enantiomer of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-ben zimidazole trihydrate, i.e. S-omeprazole magnesium salt trihydrate. The present invention also relates to the S-omeprazole magnesium salt trihydrate prepared in accordance with the new process and pharmaceutical compositions containing it. Furthermore, the present invention also relates to new intermediates ...

A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to cleaving the oligonucleotide from the solid support removing the acetonitrile; and cleaving the oligonucleotide from the solid support. The process is particularly suited to the large scale synthesis of nucleotides.

The invention relates to a process for the preparation of propylene oxide and an alkenyl aryl, which process involves: (1) reacting an alkyl aryl hydroperoxide with propene to yield propylene oxide and an aryl alcohol; and, (2) contacting, at elevated temperature, feed containing the aryl alcohol obtained in step (1) with a heterogeneous dehydration catalyst to yield an alkenyl aryl, in which process the feed of step (2) has at most 0.30% wt of compounds having a molecular weight of at least 195...

The invention relates to a process for converting 1-phenylethanol into styrene, which process involves: (1) contacting a feed containing 1-phenylethanol, organic acid and 2-phenylethanol with a catalyst to obtain a product containing styrene, and (2) removing ester compounds based on 2-phenylethanol and organic acid from the product of step (1), in which process the feed of step (1) has a molar ratio of organic acid to 2-phenylethanol of at least 1:10.

An integrated process for preparing .alpha.-(2,4-disulfophenyl)-N-tert-butylnitrone and its salts is disclosed in which N-tert-butylhydroxylamine acid addition salt is incompletely neutralised so as to leave catalytic amounts of acid and the neutralisation product is condensed with an appropriate aldehyde.

##STR1## Compounds of structure (1) are obtained by reduction of compounds of the structures ##STR2## ##STR3## Compounds of structure (1), especially where Z is a hydrogen atom or a 3,4-methylenedioxyphenyl group, are important intermediates for inter alia paroxetine.

A process for the production of a fluorescent whitening agent of formula: ##STR1## in which X and Z are as defined herein, comprising A) rearranging a hydrazobenzene compound having the formula: ##STR2## in which Z is as defined herein, to produce in situ a compound having the formula: ##STR3## B) diazotising the compound of formula (3) to produce a compound having the formula: ##STR4## in which Z has its previous significance and G.sub.1 is a counter ion; and C) reacting the compound of formula...