The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

The present invention is directed to a new class of 6-sulfonamide quinoline and chromene derivative and to their use as androgen antagonists.

A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.

Sulfonamide derivatives of the general formula (I): ##STR1## wherein preferably R.sup.1 represents a lower alkoxy group, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 may be the same or different from one another and each represent a hydrogen atom, halogen atom or lower alkyl group, A and B may be the same or different from each other and each represent .dbd.N-- or .dbd.CH--, E represents an aromatic 6-membered cyclic group, which may have 1 or 2 nitrogen atoms in the ring, and be subs...

The sulfonamide derivative according to the present invention is expressed by a general formula: ##STR1## (where R represents an alkyl group. --X represents --L.sub.12 --COOM or ##STR2## and Y-- represents R--SO.sub.2 NH--L.sub.11 -- or MOOC--L.sub.12 --. Each of L.sub.11 and L.sub.12 represents an alkylene group. Z is identical to Y, and M represents a hydrogen atom or a cation. However, X and Y cannot be --L.sub.12 --COOM at the same time. W represents an alkylene group or a cycloalkylene grou...

A sulfonamide derivative of the general formula: wherein, R.sup.1 represents (i) COOR.sup.11, (ii) CH.sub.2 OR.sup.12 or (iii) CONR.sup.13 R.sup.14, Tx--represents ##STR1## X.sub.b represents (i) bond, (ii) alkylene group of from 1 to 4 carbon atoms or (iii) alkenylene group of from 2 to 4 carbon atoms (with the proviso that --CH.dbd.CHCH.sub.2 -- and --CH.sub.2 CH.dbd.CHCH.sub.2 -- are excluded), R.sup.2b represents (i) hydrogen atom, (ii) halogen atom or (iii) alkyl group of from 1 to 4 carbon...

Since sulfonamide derivatives of the present invention show strong inhibitory activity against cysteine protease such as calpain papain, cathepsin B, cathepsin H, cathepsin L, they can be used as remedies for muscular dystrophy, cataract, myocardial infarction, stroke, Alzheimer's disease, amyotrophia, osteoporosis, hypercalcemia or the like.

A sulfonamide derivative represented by the Formula: ##STR1## wherein A, B, X, Y, R, m and n are as defined in the specification, and a salt thereof have thromboxane A.sub.2 antagonism, therefore they are useful, for example, as blood platelet aggregation inhibiting agents.

Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.

The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.