This invention relates to a novel method of synthesizing di- and triarylmethane dye precursor compounds possessing a thiolactone ring-closing moiety, from the corresponding lactones.

A process for the production of disubstituted bile acid analogs, including the disubstituted analogs of such bile acids as, lithocholic, hyodeoxycholic, cholic, chenodeoxycholic and ursodeoxycholic acids. This invention was made in the course of work performed under a grant from the U.S. National Heart Lung and Blood Institute.

There is disclosed a compound represented by the formula ##STR1## wherein each P is hydrogen or a hydroxy protecting group and R and R' are each the same and are hydrogen, ##STR2## wherein R" is lower alkyl and R'" is a carboxy protecting group. The compounds are useful as intermediates for preparing penems.

Methylaluminoxane can be formed by the reaction of a tetraalkyldialuminoxane containing C.sub.2 or higher alkyl groups with trimethylaluminum with the trimethylaluminum being present in an amount which is not present in stoichiometric excess. Another embodiment of the present invention involves the synthesis of the methylaluminoxane by reaction of a trialkylaluminum compound or a tetraalkyldialuminoxane containing C.sub.2 or higher alkyl groups with water to form a polyalkylaluminoxane which is ...

The conversion of ortho-hydroxylated Mannich bases to the corresponding methylated compounds, e.g., cresols, can be effectively carried out using a novel hydrogenation technique.

o-Iodoaryl allyl ethers undergo facile palladium-promoted cyclization to benzofurans.

The invention provides an inexpensive synthesis process for preparation of diethynylbenzene monomers that are useful in the preparation of polyacetylenes. This process provides for the preparation of thermally sensitive monomers in a one-pot reaction using readily available materials at low temperatures in an environment capable of absorbing large amounts of energy. Divinylbenzene is first brominated and then dehydrobrominated with sodium hydroxide or potassium hydroxide preferably in the presen...

This invention relates to an improved process for producing morpholine. The improvement resides in continuously charging the diethylene glycol and ammonia to a first trickle bed reactor, operating the reactor under conditions such that the diethylene glycol is maintained as a discontinuous liquid phase and the morpholine formed is predominantly in the vapor phase, separating the reaction products into a morpholine stream and a 2-(2,aminoethoxy)ethanol stream, and then charging the 2-(2,aminoetho...

The natural 3S, 4S isomer of the protected amino acid Boc-statine can be efficiently produced in large quantities using a novel method.

Carbon dioxide is removed from a raw gas containing hydrogen, carbon dioxide, and intermediate boiling gas, e.g. nitrogen, to give a gas suitable for use as a synthesis gas by a wet carbon dioxide removal process, and the resultant carbon dioxide depleted gas is subjected to pressure swing adsorption (PSA) to remove some, or all, of the intermediate boiling gas and the bulk of any residual carbon dioxide. The PSA waste gas is used to strip the absorbent liquid in the regeneration of the latter i...