The novel compound ##SPC1## Is a hydrosoluble dyestuff and when mixed, in an amount of 5-15% with 35-60% of each of the compounds: ##SPC2## And ##SPC3## Gives unusually good dyeings on cellulosic fibers, nitrogenous fibers and leather in black shades with reddish to greenish nuances.

Fluoro-substituted phenothiazine derivatives as well as their non-toxic pharmaceutically acceptable acid addition salts having pronounced neuroleptic properties and a relatively low degree of undesired side effects, a method for the preparation of said derivatives, pharmaceutical compositions containing same which may be administered to animals, including human beings, orally or parenterally.

A polymer having one of the general formulae ##EQU1## and ##EQU2## wherein Ar.sub.1, Ar.sub.2, Ar.sub.3, Ar.sub.4, Ar.sub.5, Ar.sub.6, Ar.sub.8, Ar.sub.9 and Ar.sub.10 are the same or different bivalent aromatic hydrocarbon radicals containing six to ten carbon atoms, Ar.sub.7 is a trivalent aromatic hydrocarbon radical containing 6 to 10 carbon atoms, and n is 30 to 120.

This invention relates to 1,8-naphthyridine compounds of the formula ##STR1## wherein X is a halogen atom especially fluorine atom, R.sub.1 is an ethyl group or a vinyl group, and R.sub.2 is a hydrogen atom or a lower alkyl group, their salts and processes for the preparation of them. The 1,8-naphthyridine compounds and their salts are useful as antibacterial agents and intermediates thereof.

The invention deals with novel peptides useful for the therapeutic treatment of infectious diseases caused by pathogenic microorganisms. Included is the peptide FR900156 having the structure: ##STR1## as well as the peptides of the structure ##STR2## wherein R.sup.1 is acyl; R.sub.b.sup.1 is hydrogen, methyl, isopropyl, hydroxymethyl, protected hydroxymethyl or benzyl; R.sup.2 is hydrogen, carboxy, protected carboxy, or a group of the formula: ##STR3## wherein R.sub.a.sup.2 is mono- or di-carbox...

Novel maytansinoids of the formula: ##STR1## wherein X is H or Cl, and R is a hydrocarbon residue or an azaheterocyclic group, said R group having at least one of water-solubilizing substituents, have antimitotic, antitumor and antimicrobial activities.

Derivatives of 5-norbicyclomycin of the formula ##STR1## wherein R represents an unsubstituted or substituted monovalent hydrocarbon radical in which one, two or more carbon atoms can be replaced by heteroatoms, and X represents a bivalent group of the formula --O-- or --N(R')--, wherein R' has one of the meanings assigned to R, whilst R and R', if both have a meaning which is different from hydrogen, can also be linked to each other through a C--C bond or an oxygen, sulphur or nitrogen atom, an...

Novel maytansinoid compounds of the formula: ##STR1## wherein X is H or Cl, R.sup.1 is an alkyl group of 2 to 4 carbon atoms and R.sup.2 is a lower alkyl group or an unsubstituted or substituted phenyl or aralkyl group, have antimitotic, antitumor and antimicrobial activities.

There are prepared compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or together represent a second bond between the carbon atom carrying R.sub.1 and R.sub.2, R.sub.1 also can be a hydroxy group, R.sub.3 is hydrogen, a C.sub.3 -C.sub.8 cycloalkyl group or a C.sub.1 -C.sub.20 alkyl group, which optionally can also contain one or two hydroxy groups and the groups R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are the same or different and are hydrogen, C.sub.1 -C.sub.6 -alkyl group...

Corticoids of the formula ##STR1## wherein X is fluorine, chlorine and R is hydrogen, C.sub.1-6 alkanoyl, benzoyl or --OCO--A--COOH wherein A is a carbon-to-carbon bond or a C.sub.1-6 hydrocarbon chain, or when R is --OCO--A--COOH, the physiologically acceptable salts thereof with a base, have high effectiveness, e.g., antiinflammatorily but with attendant low side effects.