Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity. ##STR00001##

Percutaneous tissue removal apparatus comprises a flexible drill shaft, a cutting tip mounted on the shaft for placement adjacent a tissue mass for cutting the tissue, means for transmitting motion to the shaft to move the cutting tip against the tissue to cut tissue fragments from the tissue, and means for removing the tissue fragments along the shaft by suction to a location outside the tissue mass while cutting. The apparatus may include means for collecting one or more selected components of...

This invention relates to shelf apparatus using rollers. In a shelf frame, conveyor devices are installed in a plurality of vertically spaced stages. Each conveyor device has two rows of roller conveyors, at least one of which is capable of generating driving power for driving loads. A space is defined between the two rows of roller conveyors to make room for installing stops adapted to stop the movement of loads or operating the fork of a fork lift truck for putting loads on and out of the shel...

A bicycle which comprises a triangular frame, a front fork including a vectorial angle of 90.degree., the length of the upper portion of the front fork being longer than that of the lower portion of the front fork, wherein the vertical arm extending from the lower portion end thereof, and a W-shaped configured rear fork which has a pair of vectorial angles of 90.degree., the lengths of the upper and lower portions of the rear fork being shorter than those of the upper and lower middle portions o...

Method and apparatus for treating sulphur bearing coal comprising pulverizing the coal, mixing it with water, a reagent and free air and pumping the resulting mixture to a classifier to separate the coal from sulphur and clay, all at the mine site. The resulting pure coal slurry is then pumped to a plant site where it is mixed with acid and bacteria. The resulting slurry is pumped to a bacteria digester wherein it is recirculated to provide maximum contact of bacteria and coal, completing the re...

A noncontact magnetic bearing has cylindrical magnetic members magnetized axially, slightly different in radius and different in length, disposed in opposite relation to each other, with their magnetic poles of reverse polarities displaced vertically relative to each other. Either the inner cylindrical magnetic member or the outer cylindrical magnetic member can be used as a shaft, and consequently, the other is fixed to a support member. The inner cylindrical magnetic member and the other cylin...

In construction of a contact-type ozonizer, one or more discharge electrodes are arranged substantially upright on a planar dielectric facing an electric field via magnetic attraction. Magnetic attraction provided stable and strong hold on the discharge electrodes without posing any excessive mechanical stress on the dielectric, upright arrangement of the discharge electrodes facilitates high rate of heat radiation and oxygen seizure is carried out in the most intensive zone of a magnetic field.

Novel packaging in a process for producing same is disclosed whereby oxygen from the interior of an enclosed container is scavenged by introducing into the container the enzyme, alcohol oxidase and its substrate, alcohol.

A mixer circuit has a first filter connected between a local oscillator terminal and a node and another filter connected between a RF signal terminal and the node. A first circuit path extends from the node through a first diode to a first tuned circuit which can be connected to an input terminal of a balanced-to-unbalanced converter. A second circuit path extends from the node through an oppositely disposed diode which is connected to another tuned circuit which can be connected to another inpu...

There is disclosed, in an immunoassay employing an immunoassay reagent comprising liposomes comprised of at least any one of phospholipids and glycolipids, a marker material enclosed in said liposomes, and an antibody or part of the antibody, or an antigen, immobilized on said liposomes by a cross-linking method, the improvement wherein a material for preventing nonspecific lysis of the liposomes is made present together in a reaction mixture.