A process that enables the formation of a high damping, soft polymer gel includes reacting a maleimide copolymer with a maleated polyalkylene and an alkyl diamine under substantially dry conditions sufficient to form a polyalkylene-grafted maleimide copolymer product which then is dispersed with an extender sufficient to form the gel. The steps can be carried out sequentially in a high shear mixer without the need for intermediate steps of cooling and grinding the reaction product of one step be…

This invention provides compounds of formula I: ##STR00001## wherein Z is oxygen or sulfur; R.sup.1 is hydrogen, –CHN.sub.2, R, CH.sub.2OR, CH.sub.2SR, or –CH.sub.2Y; next to R.sup.3 represents a single or double bond; Y is an electronegative leaving group; R.sup.2 is CO.sub.2H, CH.sub.2CO.sub.2H, or esters, amides or isosteres thereof; R.sup.3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R.sup.4 is a hydrogen or C.sub.1-6 alkyl or R.sup.3 and R.sup.4 taken together f…

The present invention provides a compound of the following formula (I): ##STR00001## wherein R.sub.1 is methyl or 4-aminobutyl, which may be acylated; X is phenyl or substituted phenyl; W is an esterified group removable by hydrogenolysis. Also disclosed is the preparation method and the application of formula (I) compound.

A multi-layered granule comprises an inner, slow-releasing layer, an outer, rapid-releasing layer and an intermediate layer provided between said slow-releasing layer and said rapid-releasing layer which intermediate layer comprises a hardened oil and hydroxypropyl cellulose or methyl cellulose.

A method of treating hypokalemia in a human by administering Kurrol’s salt in an amount effective to elevate serum potassium of the human to the range of about 3.5 mmole/l to 5.5 mmole/l.

The object of the invention is a composition for the local treatment of the epidermis comprising at least two active constituents, characterized in that one of these constituents is a product resulting from the condensation of N-methyl-p-methoxyphenethylamine with formaldehyde or product of the aromatic polyamine-type. It particularly relates to a composition for treating the scalp, particularly for treating alopeciae and alopecia aerata or pelada comprising, as second active constituent, a plac…

The invention relates to a method for applying a protective coating to a substrate, such as metallic pipe, which comprises applying onto the substrate a liquid curable polymeric composition capable of curing to a substantial extent within about 24 hours at less than about 80.degree. C., then applying one or more polymeric layers, the innermost of which is capable of interacting with said curable composition, and permitting the composition to cure. In certain embodiments the polymeric layer is ap…

A solubility modulated drug delivery device for controlled release of a therapeutically active ingredient into an environment of use is disclosed. The device comprises a core composition of a solubility modulating agent consisting of a complexing agent or a surfactant and a diffusible, water soluble, therapeutically active agent. The core composition is surrounded by a water insoluble semipermeable wall which is substantially impermeable to the core composition and permeable to the fluids in the…

The present invention discloses a phosphate adsorbent comprising an MgO-TiO.sub.2 complex as an active ingredient and a phosphate adsorbent having said complex deposited on active carbons. In the preferred embodiments of the present invention, the MgO/TiO.sub.2 molar ratio in the complex is in the range of 99.99/0.01 to 80/20, the specific surface area of the adsorbent as measured by BET method is in the range of 50 to 700 m.sup.2 /g. and the absorbent shows a crystal diffraction pattern of MgO …

An antithrombogenic, non-calcifying, and elastic material on a basis of polyurethane, characterized by the addition of fatty-acid esters and optionally by the further addition of cross-linking agents that react with water.