The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) ##STR00001## to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of cardiovascular disorders.

Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.

N-substituted derivatives of 5-oximinobarbituric add of the general formula ##STR00001## where X is sulfur; R.sub.1 is selected from the group consisting of saturated or unsaturated alkyl, cycloalkyl, aryl and arylalkyl; and R.sub.2 is selected from the group consisting of hydrogen, saturated or unsaturated alkyl, cycloalkyl, aryl and arylalkyl possessing a biological activity.

The invention relates to compounds of the general formula (I): ##STR00001## wherein Ar is optionally substituted aryl or heteroaryl; A is (i) –O–, –S–, –SO.sub.2–, –NH–, (ii) a C.sub.1-4-alkyl- or C.sub.1-6-acyl-substituted nitrogen atom or (iii) a C.sub.1-8-alkylene chain or a heteroalkylene chain having 2 to 8 chain atoms, which optionally contains at least one unsaturation, and which may be substituted and/or contain a bridge to form a saturated or partially or fully unsaturated ring …

The invention relates to the use of compounds of formula (I), wherein ring C is an 8, 9, 10, 12 or 13-membered bicyclic or tricyclic moiety which optionally may contain 1 3 heteroatoms selected independently from O, N and S; Z is –O–, –NH–, –S–, –CH.sub.2– or a direct bond; n is 0 5; m is 0 3; R.sup.2 represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C.sub.1-3alkyl, C.sub.1-3alkoxy, C.sub.1-3alkylsulphanyl, –NR.sup.3R.sup.4 (wherein R.sup.3 and R.sup.4, which may be…

The invention provides compounds of formula I: ##STR00001## whereinA, B, W, Y, Z, and R.sub.1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.

New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer’s disease and other neurodegenerative disorders, obesity, atheroscle…

An object of the present invention is to provide a new .mu.-oxo bridged heterometal compound, which can make the photo-functional materials to have diversified properties, and a production method such that the .mu.-oxo bridged heterometal compound is obtained simply, selectively and with high yield. The present invention provides .mu.-oxo bridged heterometal compounds, NcM1-O-M2Nc, PcM1-O-M2Nc and NcM1-O-M2Pc wherein Nc represents naphthalocyanine, Pc represents phthalocyanine, M1 represents a m…

Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative disea…

Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.