New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3’diindolylmethane (LTr-1), acceptable carriers and/or excipients. These compositions are administered to prevent or reduce symptoms associated with mastalgia, endometriosis and HPV-related conditions including cervical dysplasia.

The invention provides methods and compositions for diagnosing and treating ectodermal disorders, particularly ectodermal dysplasia syndromes such as Clouston syndrome, which are associated with misexpression of a TAJ gene. Methods detect the presence of or predisposition to an ectodermal disorder by (a) detecting the presence of a TAJ gene or gene product in a cell; and (b) correlating the presence of the TAJ gene or gene product with a presence of or predisposition to an ectodermal disorder. O…

The DNA and amino acid sequences are disclosed for a ligand (EDA1-II) and receptor (dl in mice and DL in humans) involved in ectodermal dysplasia. Also disclosed are variant DNA and amino acid sequences, and therapeutic applications of the ligands and receptors.

The invention relates to a pharmaceutical composition comprising copper sulfate as active agent which is effective for the diagnosis and treatment of genital dysplasia associated with viral condylomatosis. The invention also relates to a method for treating patients with the copper sulfate composition of the invention for detecting the existence of genital dysplasia and for curing such abnormality in the human organism.

A method for determining the hip joint laxity of a dog includes the steps of positioning the hip joints of the dog, in a coordinate system having three degrees of freedom, a first degree of freedom for flexion and extension of the hip joint, a second degree of freedom for adduction and abduction of the hip joint, and a third degree of freedom for internal and external rotation of the hip joint, where a neutral position is defined as positioning of an axis of the femur perpendicular to a plane de…

Methods of using probes and probe sets for the detection of high grade dysplasia and carcinoma in cervical cells are described. Methods of the invention include hybridizing one or more chromosomal probes to a biological sample obtained from a subject and detecting the hybridization pattern of the chromosomal probes to the sample to determine whether the subject has high grade dysplasia or carcinoma. Methods of the invention also include preliminary screening the cells for a marker associated wit…

In an orthopedic device for treating hip dysplasia and hip dislocation, a pelvis-supporting portion is provided with two angular projections extending in the region of natural hip joints of a patient and each carrying a pivot joint including rotation discs to which a curved guide is connected. The curved guide of each pivot joint has a longitudinal slot in which an end of an upper shank guide bar is displaceable and arrestable in any desired position. Two upper shank guide bars carrying the resp…

A prosthetic device suitable for treating canine hip dysplasia and lumbosacral disorders and method of use. The prosthetic device comprises a harness attachable to the canine. Complementary rear braces are provided comprising a right brace and a left brace wherein the right brace comprises a right leg strap for encircling the right leg of the canine, and the left brace comprises a left leg strap for encircling the left leg of the canine. The right brace and left brace are engageable to apply for…

A method for measuring functional laxity in a dog for determining presence of or absence of canine hip dysplasia is provided by placing the dog in a weight-bearing position; and assessing hip joint subluxation by an imaging technique by estimating a degree of dorsolateral subluxation for each hip joint of the positioned dog, with the degree of dorsolateral subluxation determined by measuring the portion of femoral head medial to the acetabulum. Also provided is an apparatus for placement and pos…

Apparatus and in vivo methods to distinguish normal and abnormal cervical tissue and to detect cervical intraepithelial neoplasia (CIN) in a diagnostic cervical tissue sample. Induced fluorescence intensity spectra from known normal cervical tissue and a diagnostic tissue sample are obtained from the same patient. Peak fluorescence intensity values for normal tissue samples are averaged, as are slope measurements from predetermined portions of spectra induced in both known normal cervical tissue…